PDF(Pubmed)
Abstract：
In this review, the authors outlined concepts and strategies to achieve immune tolerance through inducing hematopoietic chimerism after solid organ transplantation and introduced challenges and opportunities in harnessing two-way alloresponses to improve outcomes after intestinal transplantation (ITx). Next, the authors discussed the dynamics and phenotypes of peripheral blood and intestinal graft T-cell subset chimerism and their association with outcomes. The authors also summarized studies on other types of immune cells after ITx and their potential participation in chimerism-mediated tolerance. The authors further discussed strategies and future directions to promote chimerism-associated tolerance after ITx to overcome rejection and minimize immunosuppression.
摘要：
在这次审查中,作者概述了实体器官移植后通过诱导造血嵌合来实现免疫耐受的概念和策略,并介绍了利用双向同种反应改善肠移植(ITx)后结局的挑战和机遇.接下来,作者讨论了外周血和肠道移植物T细胞亚群嵌合体的动力学和表型及其与结局的关系.作者还总结了对ITx后其他类型免疫细胞的研究及其可能参与嵌合体介导的耐受性。作者进一步讨论了促进ITx后嵌合体相关耐受性的策略和未来方向，以克服排斥反应并最小化免疫抑制。
