{Reference Type}: Journal Article
{Title}: Chimerism-Mediated Tolerance in Intestinal Transplantation.
{Author}: Crosby K;Long KD;Fu J;
{Journal}: Gastroenterol Clin North Am
{Volume}: 53
{Issue}: 3
{Year}: 2024 Sep
{Factor}: 3.867
{DOI}: 10.1016/j.gtc.2023.12.009
{Abstract}: In this review, the authors outlined concepts and strategies to achieve immune tolerance through inducing hematopoietic chimerism after solid organ transplantation and introduced challenges and opportunities in harnessing two-way alloresponses to improve outcomes after intestinal transplantation (ITx). Next, the authors discussed the dynamics and phenotypes of peripheral blood and intestinal graft T-cell subset chimerism and their association with outcomes. The authors also summarized studies on other types of immune cells after ITx and their potential participation in chimerism-mediated tolerance. The authors further discussed strategies and future directions to promote chimerism-associated tolerance after ITx to overcome rejection and minimize immunosuppression.