PDF(Pubmed)
Abstract：
Little is known about the frequency of Zika virus (ZIKV) infections in Sudan. The aim of this study was to obtain data on the prevalence of ZIKV infections and the immunity of the population in the country. To this end, 198 sera obtained between December 2012 and January 2013 in different regions in Sudan were examined for neutralizing antibodies against ZIKV, dengue virus (DENV), and yellow fever virus (YFV). The sera were non-randomly selected. The neutralization titers were compared with each other and with the WHO 1st International Standard for anti-Asian lineage Zika virus antibody. Twenty-six sera neutralized ZIKV. One-third of these sera had higher neutralization titers against ZIKV than against DENV-2 and -3. Two sera showed higher neutralization titers than the WHO standard for ZIKV antibodies. These data suggest occasional ZIKV infections in Sudan. The low percentage of sera in this cohort that neutralized ZIKV indicates that, in the study period, the population was susceptible to ZIKV infection.
摘要：
人们对苏丹寨卡病毒（ZIKV）感染的频率知之甚少。这项研究的目的是获得有关ZIKV感染的患病率和该国人口免疫力的数据。为此,2012年12月至2013年1月在苏丹不同地区获得的198份血清进行了抗ZIKV的中和抗体检测，登革热病毒（DENV），黄热病病毒（YFV）。血清是非随机选择的。将中和滴度相互比较，并与WHO第1号抗亚洲谱系寨卡病毒抗体国际标准进行比较。26份血清中和ZIKV。这些血清的三分之一对ZIKV的中和滴度高于对DENV-2和-3的中和滴度。两种血清显示出比WHO标准的ZIKV抗体更高的中和滴度。这些数据表明苏丹偶尔发生ZIKV感染。该队列中和ZIKV的血清百分比较低表明，在学习期间，人群易感ZIKV感染.
