PDF(Pubmed)
Abstract：
Exosomes are small membrane vesicles in a cell culture. They are secreted by most cells and originate from the endosomal pathway. A variety of proteins, lipids, and genetic materials have been shown to be carried by exosomes. Once taken up by neighboring or distant cells, the bioactive compounds in exosomes can regulate the condition of recipient cells. Typically, producing exosomes in large quantities requires cell culture, resulting in high production costs. However, exosomes are abundant in milk and can be isolated on a large scale at a low cost. In our study, we found that milk exosomes can promote the synthesis and reconstruction of stratum corneum lipids, enhance skin barrier function, and provide greater protection for the skin. Furthermore, milk exosomes have anti-inflammatory properties that can reduce skin irritation, redness, and other symptoms, giving immediate relief. They also exhibit antioxidant activity, which helps neutralize free radicals and slows down the skin aging process. Additionally, milk exosomes inhibit melanin production, aiding in skin whitening. Ongoing research has uncovered the benefits of milk exosomes for skin improvement and their application in cosmetics, skin healthcare, and other fields, and these applications are continuing to expand.
摘要：
外泌体是细胞培养物中的小膜囊泡。它们由大多数细胞分泌并且源自内体途径。各种各样的蛋白质，脂质，和遗传物质已被证明是由外泌体携带的。一旦被邻近或遥远的细胞占据，外泌体中的生物活性化合物可以调节受体细胞的状况。通常,大量生产外泌体需要细胞培养，导致生产成本高。然而,外泌体在牛奶中含量丰富，可以低成本大规模分离。在我们的研究中,我们发现牛奶外泌体可以促进角质层脂质的合成和重建，增强皮肤屏障功能，并为皮肤提供更大的保护。此外，牛奶外泌体具有抗炎特性，可以减少皮肤刺激，发红,和其他症状，立即给予救济。它们还表现出抗氧化活性，这有助于中和自由基，减缓皮肤老化过程。此外,牛奶外泌体抑制黑色素的产生，帮助皮肤美白。正在进行的研究发现了牛奶外泌体对皮肤改善的好处及其在化妆品中的应用，皮肤保健，和其他领域，这些应用程序正在继续扩展。
