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Abstract：
This meta-analysis investigated the effects of intravenous magnesium sulfate on the postoperative recovery quality, as assessed using the Quality of Recovery (QoR) questionnaire, in adult surgical patients. Seven randomized controlled trials involving 622 patients were included. Compared with the placebo, magnesium sulfate significantly improved the global QoR score on postoperative day 1 (standardized mean difference [SMD]: 1.24; 95% confidence interval: 0.70-1.78; p < 0.00001). It also enhanced specific QoR dimensions, with substantial effects on pain (SMD: 1, p < 0.00001) and physical comfort (SMD: 0.85, p < 0.0001), a moderate effect on emotional state (SMD: 0.65, p = 0.002), and small improvements in physical independence (SMD: 0.43, p < 0.00001) and psychological support (SMD: 0.37, p < 0.0001). In addition, magnesium sulfate reduced the intraoperative opioid consumption (SMD: -0.66, p < 0.0001), postoperative pain severity, and the incidence of postoperative nausea and vomiting (risk ratio: 0.48, p = 0.008). The extubation times were unaffected, whereas the post-anesthesia care unit stay was slightly prolonged. These findings highlight the potential of magnesium sulfate as a valuable adjunct for multimodal analgesia and enhanced recovery. Future studies should aim to elucidate the optimal dosing strategies, timing of administration, and specific surgical populations that may derive maximum benefits.
摘要：
本荟萃分析探讨静脉硫酸镁对术后恢复质量的影响。如使用恢复质量(QoR)问卷评估的，成人手术患者。纳入7项随机对照试验，涉及622例患者。与安慰剂相比，硫酸镁显著改善了术后第1天的整体QoR评分(标准化平均差[SMD]:1.24;95%置信区间:0.70-1.78;p<0.00001).它还增强了特定的QoR维度，对疼痛（SMD：1，p<0.00001）和身体舒适度（SMD：0.85，p<0.0001）有实质性影响，对情绪状态的中等影响（SMD：0.65，p=0.002），身体独立性（SMD：0.43，p<0.00001）和心理支持（SMD：0.37，p<0.0001）略有改善。此外,硫酸镁减少了术中阿片类药物的消耗（SMD：-0.66，p<0.0001），术后疼痛严重程度，术后恶心和呕吐的发生率（风险比：0.48，p=0.008）。拔管时间不受影响,而麻醉后监护病房的住院时间稍长.这些发现强调了硫酸镁作为多模式镇痛和增强恢复的有价值的辅助手段的潜力。未来的研究应旨在阐明最佳给药策略，管理的时机,以及可能获得最大益处的特定手术人群。
