PDF(Pubmed)
Abstract：
Vitamin D deficiency has been associated with a higher risk of multiple diseases, including cardiovascular disorders. The purpose of this study was to examine the potential association between predicted levels of serum 25(OH)D and the risk of new-onset hypertension in a large Mediterranean cohort. A validated 136-item food frequency questionnaire was used as the dietary assessment tool. 25(OH)D serum levels were predicted using a previously validated equation. We performed Cox regression models to analyze the association between predicted serum 25(OH)D and the risk of hypertension, according to quartiles of forecasted vitamin D at baseline, after adjusting for multiple potential confounders. Over a median follow-up of 12.3 years, 2338 new cases of hypertension were identified. The analyses revealed a significant inverse association between predicted serum levels of 25(OH)D at baseline and the risk of hypertension. Individuals in the highest quartile showed a 30% relatively lower risk of hypertension compared to the lowest quartile (hazard ratio (HR): 0.70; 95% confidence interval (CI): 0.60-0.80, p-trend < 0.001). The outcomes remained significant after performing sensitivity analyses. The findings suggested that higher levels of forecasted vitamin D are inversely and independently associated with the risk of incident hypertension, implying that vitamin D may offer protective benefits against the disease.
摘要：
维生素D缺乏与多种疾病的高风险有关，包括心血管疾病.这项研究的目的是研究地中海大型队列中血清25（OH）D预测水平与新发高血压风险之间的潜在关联。使用经过验证的136项食物频率问卷作为饮食评估工具。使用先前验证的方程预测25(OH)D血清水平。我们使用Cox回归模型来分析预测的血清25(OH)D与高血压风险之间的关系。根据基线预测的维生素D的四分位数，在调整了多个潜在的混杂因素后。在12.3年的中位随访时间内，发现了2338例新的高血压病例。分析显示，基线时25（OH）D的预测血清水平与高血压风险之间存在显着负相关。与最低四分位数相比，最高四分位数的个体患高血压的风险相对较低30％（风险比（HR）：0.70；95％置信区间（CI）：0.60-0.80，p趋势<0.001）。在进行敏感性分析后，结果仍然显著。研究结果表明，较高的预测维生素D水平与高血压事件的风险成反比且独立相关。这意味着维生素D可能对这种疾病有保护作用。
