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Abstract：
Ageratum conyzoides, an annual herbaceous plant that inhabits tropical and subtropical regions, has been traditionally used in Asia, Africa, and South America for phytotherapy to treat infectious and inflammatory conditions. However, the pharmacological effects of standardized ethanolic extract of Ageratum conyzoides (ACE) on benign prostatic hyperplasia (BPH) remain unexplored. The objective of this research is to examine the potential physiological impacts of ACE, a traditionally utilized remedy for inflammatory ailments, in a rat model with BPH induced by testosterone propionate (TP). Rats were subcutaneously administered TP (3 mg/kg) to induce BPH and concurrently orally administered ACE (20, 50, and 100 mg/kg) daily for 42 days. ACE markedly improved BPH characteristics, including prostate weight, prostate index, and epithelial thickness, while also suppressing androgens and related hormones. The findings were supported by a decrease in androgen receptor and downstream signals associated with BPH in the prostate tissues of the ACE groups. Furthermore, increased apoptotic signals were observed in the prostate tissue of the ACE groups, along with heightened detection of the apoptotic nucleus compared to the BPH alone group. These changes seen in the group that received finasteride were similar to those observed in this group. These findings suggest that ACE shows promise as an alternative phytotherapeutic agent for treating BPH.
摘要：
麻黄,一种一年生草本植物，栖息在热带和亚热带地区，传统上在亚洲使用，非洲,和南美的植物疗法来治疗传染病和炎症。然而,标准化香菇乙醇提取物（ACE）对良性前列腺增生（BPH）的药理作用仍未被研究。这项研究的目的是检查ACE的潜在生理影响，一种传统上用于治疗炎症性疾病的药物，在丙酸睾酮（TP）诱导的BPH大鼠模型中。每天皮下给予大鼠TP(3mg/kg)以诱导BPH,并同时口服给予ACE(20、50和100mg/kg),持续42天。ACE显著改善BPH特性，包括前列腺重量,前列腺指数,和上皮厚度，同时还抑制雄激素和相关激素。该发现得到ACE组前列腺组织中雄激素受体和与BPH相关的下游信号减少的支持。此外，在ACE组的前列腺组织中观察到凋亡信号增加，与单独的BPH组相比，凋亡核的检测增强。在接受非那雄胺的组中观察到的这些变化与该组中观察到的变化相似。这些发现表明，ACE有望作为治疗BPH的替代植物治疗剂。
