PDF(Pubmed)
Abstract：
Background: Esophageal cancer (EC) comprises 1% of all diagnosed cancers in the USA. It is more common in other parts of the world. If there is distant metastasis, the relative survival rate is 6%. There are no standardized screening methods for EC. Case Presentation: We reported a four-year case of esophageal cancer, a P53-positive mutation with atypical distant metastasis to the cardiac and skeletal muscles. The patient was managed with multimodal therapy, including immunotherapy, which could have been a factor in prolonged survival. Conclusions: Distant metastases are typically seen postmortem, and with prolonged survival, we are able to find such unique metastases antemortem. Despite a history of negative scans, the patient\'s ctDNA (circulating tumor DNA) remained positive, which was a better predictor of recurrence in this case. Future research is required to establish cost-effective screening methods and standardized treatments.
摘要：
背景：食管癌（EC）占美国所有诊断癌症的1％。这在世界其他地区更为常见。如果有远处转移,相对存活率为6%。没有针对EC的标准化筛选方法。病例介绍：我们报道了一个为期四年的食管癌病例，一种P53阳性突变，伴有心肌和骨骼肌的非典型远处转移。患者接受了多模式治疗，包括免疫疗法,这可能是延长生存期的一个因素。结论：远处转移通常在死后看到，随着生存期的延长，我们能够在死前找到这种独特的转移。尽管有负面扫描的历史，患者的ctDNA（循环肿瘤DNA）保持阳性，在这种情况下，这是一个更好的复发预测指标。未来的研究需要建立具有成本效益的筛查方法和标准化治疗。
