关键词: bioprinting conformal 3D printing in situ printing tissue repair

来  源:   DOI:10.3390/mi15070920   PDF(Pubmed)

Abstract:
Conformal 3D printing can construct specific three-dimensional structures on the free-form surfaces of target objects, achieving in situ additive manufacturing and repair, making it one of the cutting-edge technologies in the current field of 3D printing. To further improve the repair efficacy in tissue engineering, this study proposes a conformal path planning algorithm for in situ printing in specific areas of the target object. By designing the conformal 3D printing algorithm and utilizing vector projection and other methods, coordinate transformation of the printing trajectory was achieved. The algorithm was validated, showing good adherence of the printing material to the target surface. In situ repair experiments were also conducted on human hands and pig tibia defect models, verifying the feasibility of this method and laying a foundation for further research in personalized medicine and tissue repair.
摘要:
共形3D打印可以在目标物体的自由曲面上构造特定的三维结构,实现原位增材制造和修复,使其成为当前3D打印领域的尖端技术之一。为进一步提高组织工程修复效果,本研究提出了在目标物体的特定区域进行原位打印的保形路径规划算法。通过设计共形3D打印算法,利用矢量投影等方法,实现了印刷轨迹的坐标变换。对算法进行了验证,显示打印材料对目标表面的良好粘附性。还在人手和猪胫骨缺损模型上进行了原位修复实验,验证了该方法的可行性,为进一步开展个性化医学和组织修复研究奠定了基础。
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