PDF(Pubmed)
Abstract：
Purpose: The present study aimed to clarify the effects of a hyperglycemic condition on the clinical consequences of long COVID. Methods: Among 643 patients who visited the outpatient clinic of our hospital from February 2021 to September 2023, long COVID patients were classified into a hyperglycemic (HG) group with casual blood glucose levels above 140 mg/dL and a normoglycemic (NG) group. The patients\' backgrounds, clinical symptoms, health status including the QOL evaluation scale (EQ-5D-5L), self-rating depression scale (SDS), and F-scale questionnaire (FSSG), blood test data, and recovery periods were analyzed. Results: The NG group included 607 patients with long COVID and the HG group included 36 patients with long COVID. Patients in the HG group were older than those in the NG group (55 vs. 41 years; p < 0.001) and included a larger percentage of males (67% vs. 44%; p = 0.009). The HG group had a larger percentage of patients with moderate-to-severe conditions in the acute infection phase (28% vs. 12%; p = 0.008), a higher BMI (25 vs. 22 kg/m2; p < 0.001), higher blood pressure (138/81 vs. 122/72 mmHg; p < 0.001), and a larger percentage of patients with an alcohol drinking habit (53% vs. 34%; p = 0.031). Long COVID symptoms and self-rated scales were not differed between the two groups; however, the laboratory data showed that liver and renal functions and metabolic data were significantly worse in the HG group. Although there was no apparent difference between the two groups in duration from the infection to the first visit, the HG group had a significantly longer period of recovery from long COVID (median period of 421 vs. 294 days; p = 0.019). Conclusion: A hyperglycemic state associated with other lifestyle-related diseases is associated with the prolongation of recovery from long COVID.
摘要：
目的：本研究旨在阐明高血糖状况对长期COVID的临床后果的影响。方法:将2021年2月至2023年9月在我院门诊就诊的643例患者中，将长期COVID患者分为血糖高于140mg/dL的高血糖(HG)组和血糖正常(NG)组。病人的背景，临床症状,健康状况，包括QOL评估量表(EQ-5D-5L)，抑郁自评量表（SDS），和F量表问卷(FSSG)，验血数据,并对恢复期进行了分析。结果：NG组包括607例长COVID患者，HG组包括36例长COVID患者。HG组患者年龄大于NG组（55vs.41岁；p<0.001)，其中男性比例更高(67%vs.44%；p=0.009）。HG组在急性感染阶段有更大比例的中度至重度疾病患者（28％vs.12%；p=0.008），较高的BMI(25vs.22kg/m2；p<0.001)，高血压（138/81vs.122/72mmHg；p<0.001），有饮酒习惯的患者比例更高(53%vs.34%；p=0.031）。长COVID症状和自评量表在两组之间没有差异；然而，实验室数据显示HG组的肝肾功能和代谢数据明显较差.尽管从感染到第一次就诊，两组之间的持续时间没有明显差异，HG组从长COVID中恢复的时间明显更长(中位时间为421vs.294天；p=0.019）。结论：与其他生活方式相关疾病相关的高血糖状态与长期COVID的恢复时间延长有关。
