PDF(Pubmed)
Abstract：
The muscarinic acetylcholine receptor M3 (M3-mAChR) is involved in various physiological and pathological processes. Owing to specific cardioprotective effects, M3-mAChR is an ideal diagnostic and therapeutic biomarker for cardiovascular diseases (CVDs). Growing evidence has linked M3-mAChR to the development of multiple CVDs, in which it plays a role in cardiac protection such as anti-arrhythmia, anti-hypertrophy, and anti-fibrosis. This review summarizes M3-mAChR\'s expression patterns, functions, and underlying mechanisms of action in CVDs, especially in ischemia/reperfusion injury, cardiac hypertrophy, and heart failure, opening up a new research direction for the treatment of CVDs.
摘要：
毒蕈碱乙酰胆碱受体M3(M3-mAChR)参与各种生理和病理过程。由于特定的心脏保护作用，M3-mAChR是心血管疾病（CVD）的理想诊断和治疗生物标志物。越来越多的证据将M3-mAChR与多种CVD的发展联系起来，它在心脏保护中发挥作用，如抗心律失常，抗肥大,和抗纤维化。这篇综述总结了M3-mAChR的表达模式，功能,以及心血管疾病的潜在作用机制，尤其是在缺血/再灌注损伤中，心脏肥大,心力衰竭,为心血管疾病的治疗开辟了新的研究方向。
