新型 2 - 芳酰基苯并呋喃基羟肟酸抗微管剂的合成及生物学评价.
关键词: anticancer agents benzo[b]furan dual-target inhibitors histone deacetylase (HDAC) tubulin
Mesh : Humans Benzofurans / pharmacology chemistry chemical synthesis Tubulin Modulators / pharmacology chemical synthesis chemistry Hydroxamic Acids / pharmacology chemistry chemical synthesis Tubulin / metabolism Antineoplastic Agents / pharmacology chemical synthesis chemistry Cell Proliferation / drug effects Histone Deacetylase Inhibitors / pharmacology chemical synthesis chemistry HeLa Cells Histone Deacetylase 6 / antagonists & inhibitors metabolism Cell Line, Tumor MCF-7 Cells Structure-Activity Relationship Drug Screening Assays, Antitumor HT29 Cells
来 源:
DOI:10.3390/ijms25147519
PDF(Pubmed)