PDF(Pubmed)
Abstract：
Interleukin-5 functions as a B-cell differentiation factor, but more importantly, in the context of this review, it plays a variety of roles in eosinophil biology, including eosinophil differentiation and maturation in the bone marrow, and facilitates eosinophil migration to tissue sites, usually in the context of an allergic reaction. Given the availability of selective anti-IL-5 drugs such as mepolizumab and reslizumab, as well as the IL-5 receptor antagonist benralizumab, it is worth investigating whether they could be used in some cases of allergic disease. Asthma has a well-documented involvement of IL-5 in its pathophysiology and has clear benefits in the case of anti-IL-5 therapy; therefore, current knowledge is presented to provide a reference point for the study of less-described diseases such as atopic dermatitis, chronic rhinosinusitis, chronic spontaneous urticaria, and its association with both IL-5 and anti-IL-5 treatment options. We then review the current literature on these diseases, explain where appropriate potential reasons why anti-IL-5 treatments are ineffective, and then point out possible future directions for further research.
摘要：
白细胞介素-5作为B细胞分化因子，但更重要的是,在这次审查的背景下，它在嗜酸性粒细胞生物学中起着多种作用，包括骨髓中嗜酸性粒细胞的分化和成熟，并促进嗜酸性粒细胞迁移到组织部位，通常在过敏反应的情况下。鉴于选择性抗IL-5药物如美泊利单抗和瑞珠单抗的可用性，以及IL-5受体拮抗剂贝那利珠单抗，值得研究它们是否可用于某些过敏性疾病。哮喘在其病理生理学中涉及IL-5，并且在抗IL-5治疗的情况下具有明显的益处;因此，当前的知识被提出，为研究描述较少的疾病，如特应性皮炎，慢性鼻-鼻窦炎,慢性自发性荨麻疹，及其与IL-5和抗IL-5治疗方案的相关性。然后，我们回顾了目前关于这些疾病的文献，解释抗IL-5治疗无效的适当潜在原因，然后指出未来可能的进一步研究方向。
