PDF(Pubmed)
Abstract：
The effect of helminthiasis on host immunity is a neglected area of research, particularly in tuberculosis (TB) infection. This study aimed to evaluate the effect of helminthiasis on immunological and haematological parameters in newly diagnosed TB patients in Bobo-Dioulasso. After all biological analyses, we formed three subpopulations: group 1 (n = 82), as control, were participants without helminthic or Mycobacterium tuberculosis complex infection (Mtb-/Helm-), group 2 (n = 73) were TB patients without helminthic infection (Mtb+/Helm-), and group 3 (n = 22) were TB patients with helminthic infection (Mtb+/Helm+). The proportion of helminth coinfection was 23.16% (22/95) in TB patients, and Schistosoma mansoni infection was found in 77.3% (17/22) cases of helminthiasis observed in this study. A low CD4 T cell count and a low CD4:CD8 ratio were significantly associated with concomitant infection with helminths and the Mtb complex (Mtb+/Helm+) compared to the other groups (p < 0.05). However, there was no statistically significant difference in the CD8 median among the three participating groups (p > 0.05). Lymphopenia, monocytosis, thrombocytosis, and hypochromic microcytic anaemia were the haematological defects observed in the Mtb+/Helm+ and Mtb+/Helm- patients. Exploring these types of immune-haematological biomarkers would be a valuable aid in diagnosing and a better follow-up and monitoring of the tuberculosis-helminthiasis coinfection.
摘要：
蠕虫病对宿主免疫的影响是一个被忽视的研究领域，特别是在结核病（TB）感染中。这项研究旨在评估蠕虫病对Bobo-Dioulasso新诊断的结核病患者的免疫学和血液学参数的影响。经过所有的生物学分析,我们形成了三个亚群：第1组（n=82），作为控制,是没有蠕虫或结核分枝杆菌复合体感染（Mtb-/Helm-）的参与者，第2组（n=73）是无蠕虫感染的结核病患者（Mtb/Helm-），第3组（n=22）为蠕虫感染（Mtb/Helm）的TB患者。结核病患者中蠕虫合并感染的比例为23.16%(22/95),在本研究中观察到的77.3％（17/22）的蠕虫病病例中发现了曼氏血吸虫感染。与其他组相比，低CD4T细胞计数和低CD4：CD8比率与蠕虫和Mtb复合物（Mtb/Helm）的伴随感染显着相关（p<0.05）。然而,3组CD8中位数差异无统计学意义(p>0.05)。淋巴细胞减少症,单核细胞增多,血小板增多症,和低色素性小细胞性贫血是Mtb/Helm和Mtb/Helm-患者中观察到的血液学缺陷。探索这些类型的免疫血液学生物标志物将是诊断和更好的随访和监测结核病-蠕虫病合并感染的有价值的帮助。
