PDF(Pubmed)
Abstract：
Researchers have studied the effects of exercise on serum methyl-arginine and vitamin D metabolites; however, the effects of exercise combined with antioxidants are not well documented. Since oxidative stress affects the metabolism of vitamin D and methyl-arginine, we hypothesised that the antioxidant coenzyme Q10 (CoQ10) might modulate exercise-induced changes. A group of twenty-eight healthy men participated in this study and were divided into two groups: an experimental group and a control group. The exercise test was performed until exhaustion, with gradually increasing intensity, before and after the 21-day CoQ10 supplementation. Blood samples were collected before, immediately after, and 3 and 24 h after exercise. CoQ10, vitamin D metabolites, asymmetric dimethylarginine (ADMA), symmetric dimethylarginine, methylarginine, dimethylamine, arginine, citrulline, and ornithine were analysed in serum samples. CoQ10 supplementation caused a 2.76-fold increase in the concentration of serum CoQ10. Conversely, the 25(OH)D3 concentration increased after exercise only in the placebo group. ADMA increased after exercise before supplementation, but a decrease was observed in the CoQ10 supplementation group 24 h after exercise. In conclusion, our data indicate that CoQ10 supplementation modifies the effects of exercise on vitamin D and methyl-arginine metabolism, suggesting its beneficial effects. These findings contribute to the understanding of how antioxidants like CoQ10 can modulate biochemical responses to exercise, potentially offering new insights for enhancing athletic performance and recovery.
摘要：
研究人员研究了运动对血清甲基精氨酸和维生素D代谢产物的影响；然而，运动结合抗氧化剂的效果没有得到很好的证明.由于氧化应激影响维生素D和甲基精氨酸的代谢，我们假设抗氧化辅酶Q10（CoQ10）可能调节运动引起的变化。一组28名健康男性参加了这项研究，并分为两组：实验组和对照组。进行运动测试直到筋疲力尽，随着强度逐渐增加，在21天补充辅酶Q10之前和之后。之前采集了血样,紧接着,运动后3和24小时。辅酶Q10，维生素D代谢产物，不对称二甲基精氨酸（ADMA），对称二甲基精氨酸，甲基精氨酸,二甲胺,精氨酸瓜氨酸,和鸟氨酸在血清样本中进行分析。补充CoQ10导致血清CoQ10浓度增加2.76倍。相反，仅在安慰剂组中,运动后25(OH)D3浓度升高.补充前运动后ADMA增加，但运动后24小时补充辅酶Q10组观察到下降。总之,我们的数据表明补充辅酶Q10可以改变运动对维生素D和甲基精氨酸代谢的影响，表明其有益效果。这些发现有助于理解CoQ10等抗氧化剂如何调节运动的生化反应，可能为提高运动表现和恢复提供新的见解。
