Abstract：
Epilepsy affects 65 million people globally and causes neurobehavioral, cognitive, and psychological defects. Although research on the disease is progressing and a wide range of treatments are available, approximately 30% of people have refractory epilepsy that cannot be managed with conventional medications. This underlines the importance of further understanding the condition and exploring cutting-edge targets for treatment. Adipokines are peptides secreted by adipocyte\'s white adipose tissue, involved in controlling food intake and metabolism. Their regulatory functions in the central nervous system (CNS) are multifaceted and identified in several physiology and pathologies. Adipokines play a role in oxidative stress and neuroinflammation which are associated with brain degeneration and connected neurological diseases. This review aims to highlight the potential impacts of leptin, adiponectin, apelin, vaspin, visfatin, and chimerin in the pathogenesis of epilepsy.
摘要：
癫痫影响全球6500万人，并导致神经行为，认知，心理缺陷。尽管对这种疾病的研究正在取得进展，并且有广泛的治疗方法，大约30%的人患有难治性癫痫,不能用常规药物治疗.这强调了进一步了解病情和探索治疗前沿目标的重要性。脂肪因子是由脂肪细胞的白色脂肪组织分泌的肽，参与控制食物摄入和新陈代谢。它们在中枢神经系统（CNS）中的调节功能是多方面的，并在几种生理学和病理学中得到了鉴定。脂肪因子在氧化应激和神经炎症中起作用，这与脑变性和相关的神经系统疾病有关。这篇综述旨在强调瘦素的潜在影响，脂联素,apelin,vaspin,visfatin,和嵌合体在癫痫发病机制中的作用。
