Abstract：
BACKGROUND: Both alcohol misuse and sleep deficiency are associated with deficits in semantic processing. However, alcohol misuse and sleep deficiency are frequently comorbid and their inter-related effects on semantic processing as well as the underlying neural mechanisms remain to be investigated.
METHODS: We curated the Human Connectome Project data of 973 young adults (508 women) to examine the neural correlates of semantic processing in link with the severity of alcohol use and sleep deficiency. The latter were each evaluated using the first principal component (PC1) of principal component analysis of all drinking metrics and the Pittsburgh Sleep Quality Index (PSQI). We employed path modeling to elucidate the interplay among clinical, behavioral, and neural variables.
RESULTS: Among women, we observed a significant negative correlation between the left precentral gyrus (PCG) and PSQI scores. Mediation analysis revealed that the left PCG activity fully mediated the relationship between PSQI scores and word comprehension in language tasks. In women alone also, the right middle frontal gyrus (MFG) exhibited a significant negative correlation with PC1. The best path model illustrated the associations among PC1, PSQI scores, PCG activity, and MFG activation during semantic processing in women.
CONCLUSIONS: Alcohol misuse may lead to reduced MFG activation while sleep deficiency hinder semantic processing by suppressing PCG activity in women. The pathway model underscores the influence of sleep quality and alcohol consumption severity on semantic processing in women, suggesting that sex differences in these effects need to be further investigated.
METHODS: We curated the Human Connectome Project data of 973 young adults (508 women) to examine the neural correlates of semantic processing in link with the severity of alcohol use and sleep deficiency. The latter were each evaluated using the first principal component (PC1) of principal component analysis of all drinking metrics and the Pittsburgh Sleep Quality Index (PSQI). We employed path modeling to elucidate the interplay among clinical, behavioral, and neural variables.
RESULTS: Among women, we observed a significant negative correlation between the left precentral gyrus (PCG) and PSQI scores. Mediation analysis revealed that the left PCG activity fully mediated the relationship between PSQI scores and word comprehension in language tasks. In women alone also, the right middle frontal gyrus (MFG) exhibited a significant negative correlation with PC1. The best path model illustrated the associations among PC1, PSQI scores, PCG activity, and MFG activation during semantic processing in women.
CONCLUSIONS: Alcohol misuse may lead to reduced MFG activation while sleep deficiency hinder semantic processing by suppressing PCG activity in women. The pathway model underscores the influence of sleep quality and alcohol consumption severity on semantic processing in women, suggesting that sex differences in these effects need to be further investigated.
摘要：
背景：酒精滥用和睡眠不足都与语义加工缺陷有关。然而,酒精滥用和睡眠不足通常是合并症，它们对语义加工以及潜在的神经机制的相关影响仍有待研究。
方法：我们整理了973名年轻成年人（508名女性）的HumanConnectomeProject数据，以检查与酒精使用和睡眠不足的严重程度相关的语义处理的神经相关性。使用所有饮酒指标的主成分分析的第一主成分（PC1）和匹兹堡睡眠质量指数（PSQI）对后者进行了评估。我们采用路径建模来阐明临床，行为，和神经变量。
结果：在女性中，我们观察到左中央前回（PCG）和PSQI评分之间存在显着负相关。中介分析显示，左侧PCG活动完全介导了PSQI分数与语言任务中单词理解之间的关系。只有女人，右额中回(MFG)与PC1呈显著负相关。最佳路径模型说明了PC1、PSQI分数、PCG活动,和MFG在女性语义加工过程中的激活。
结论：酒精误用可能导致MFG激活减少，而睡眠不足通过抑制女性PCG活性阻碍语义加工。路径模型强调了睡眠质量和饮酒严重程度对女性语义加工的影响，这表明这些影响的性别差异需要进一步研究。
方法：我们整理了973名年轻成年人（508名女性）的HumanConnectomeProject数据，以检查与酒精使用和睡眠不足的严重程度相关的语义处理的神经相关性。使用所有饮酒指标的主成分分析的第一主成分（PC1）和匹兹堡睡眠质量指数（PSQI）对后者进行了评估。我们采用路径建模来阐明临床，行为，和神经变量。
结果：在女性中，我们观察到左中央前回（PCG）和PSQI评分之间存在显着负相关。中介分析显示，左侧PCG活动完全介导了PSQI分数与语言任务中单词理解之间的关系。只有女人，右额中回(MFG)与PC1呈显著负相关。最佳路径模型说明了PC1、PSQI分数、PCG活动,和MFG在女性语义加工过程中的激活。
结论：酒精误用可能导致MFG激活减少，而睡眠不足通过抑制女性PCG活性阻碍语义加工。路径模型强调了睡眠质量和饮酒严重程度对女性语义加工的影响，这表明这些影响的性别差异需要进一步研究。
