Abstract：
Asymmetric cell division (ACD) plays a pivotal role in development, tissue homeostasis, and stem cell maintenance. Emerging evidence suggests that long non-coding RNAs (lncRNAs) are key regulators of ACD, orchestrating the intricate molecular machinery that governs cell fate determination. This review summarizes current literature to elucidate the diverse roles of lncRNAs in modulating ACD across various biological contexts. The regulatory mechanisms of asymmetric cell division mediated by lncRNAs, including their interactions with protein effectors, epigenetic regulation, and subcellular localization are explored. Additionally, we discuss the implications of dysregulated lncRNAs in mediating ACD that lead to tumorigenesis. By integrating findings from diverse experimental models and cell types, this review provides insights into the multifaceted roles of lncRNAs in governing asymmetric cell division, shedding light on fundamental biological processes. Further research in this area may lead to the development of novel therapies targeting dysregulated lncRNAs to restore proper cell division and function. The knowledge of lncRNAs regulating ACD could potentially revolutionize the field of regenerative medicine and cancer therapy by targeting specific lncRNAs involved in ACD. By unraveling the complex interactions between lncRNAs and cellular processes, the potential novel opportunities for precision medicine approaches may be uncovered.
摘要：
不对称细胞分裂（ACD）在发育中起着关键作用，组织稳态，和干细胞维护。新出现的证据表明，长链非编码RNA（lncRNAs）是ACD的关键调节因子，协调控制细胞命运决定的复杂分子机制。这篇综述总结了当前的文献，以阐明lncRNAs在各种生物学环境中调节ACD的不同作用。lncRNAs介导的不对称细胞分裂的调控机制，包括它们与蛋白质效应物的相互作用，表观遗传调控，探索亚细胞定位。此外,我们讨论了lncRNAs失调在介导导致肿瘤发生的ACD中的意义。通过整合来自不同实验模型和细胞类型的发现，这篇综述提供了对lncRNAs在控制不对称细胞分裂中的多方面作用的见解，揭示基本的生物过程。该领域的进一步研究可能导致开发针对失调的lncRNAs的新疗法，以恢复适当的细胞分裂和功能。调节ACD的lncRNAs的知识可能通过靶向参与ACD的特定lncRNAs来彻底改变再生医学和癌症治疗领域。通过解开lncRNAs和细胞过程之间复杂的相互作用，可能会发现精准医学方法的潜在新机遇。
