PDF(Pubmed)
Abstract：
BACKGROUND: Hyalinizing clear cell carcinoma (HCCC) of the salivary glands is a rare low-grade malignant tumor. This type of tumor is particularly uncommon in the sublingual glands.
METHODS: A 57-year-old female with a mass on the left side of the floor of the mouth that had been present for 2 months. The computed tomography scan of the neck revealed a nodular abnormal density shadow in the left sublingual area, measuring approximately 2.6 cm × 1.9 cm.
METHODS: Primary HCCC of the sublingual gland.
METHODS: The patient underwent surgical treatment and reconstruction using a left anterolateral femoral free flap, which showed immunohistochemical positivity for CK 5/6, CK 7, CK (AE1/AE3), and Ki-67 (<5%), but negative for SMA and S-100.
RESULTS: No recurrence was observed during the 12-month postoperative follow-up period.
CONCLUSIONS: The absence of characteristic clinical manifestations makes HCCC highly susceptible to misdiagnoses. This case presents a rare instance of HCCC in the sublingual gland, providing a reference for the clinical diagnosis and treatment of the disease.
METHODS: A 57-year-old female with a mass on the left side of the floor of the mouth that had been present for 2 months. The computed tomography scan of the neck revealed a nodular abnormal density shadow in the left sublingual area, measuring approximately 2.6 cm × 1.9 cm.
METHODS: Primary HCCC of the sublingual gland.
METHODS: The patient underwent surgical treatment and reconstruction using a left anterolateral femoral free flap, which showed immunohistochemical positivity for CK 5/6, CK 7, CK (AE1/AE3), and Ki-67 (<5%), but negative for SMA and S-100.
RESULTS: No recurrence was observed during the 12-month postoperative follow-up period.
CONCLUSIONS: The absence of characteristic clinical manifestations makes HCCC highly susceptible to misdiagnoses. This case presents a rare instance of HCCC in the sublingual gland, providing a reference for the clinical diagnosis and treatment of the disease.
摘要：
背景：唾液腺透明透明细胞癌（HCCC）是一种罕见的低度恶性肿瘤。这种类型的肿瘤在舌下腺中特别罕见。
方法：一名57岁女性，嘴底左侧有肿块，已经存在2个月。颈部计算机断层扫描显示左侧舌下区域有结节状异常密度影，约2.6厘米×1.9厘米。
方法：舌下腺原发性HCCC。
方法：患者使用左股前外侧游离皮瓣进行手术治疗和重建，显示CK5/6，CK7，CK（AE1/AE3）的免疫组织化学阳性，和Ki-67（<5%），但SMA和S-100阴性.
结果：术后12个月随访期间未见复发。
结论：由于缺乏特征性临床表现，HCCC极易被误诊。此例表现为舌下腺HCCC的罕见病例，为该病的临床诊断和治疗提供参考。
方法：一名57岁女性，嘴底左侧有肿块，已经存在2个月。颈部计算机断层扫描显示左侧舌下区域有结节状异常密度影，约2.6厘米×1.9厘米。
方法：舌下腺原发性HCCC。
方法：患者使用左股前外侧游离皮瓣进行手术治疗和重建，显示CK5/6，CK7，CK（AE1/AE3）的免疫组织化学阳性，和Ki-67（<5%），但SMA和S-100阴性.
结果：术后12个月随访期间未见复发。
结论：由于缺乏特征性临床表现，HCCC极易被误诊。此例表现为舌下腺HCCC的罕见病例，为该病的临床诊断和治疗提供参考。
