{Reference Type}: Case Reports
{Title}: Hyalinizing clear cell carcinoma of the sublingual gland: A case report and literature review.
{Author}: Guan L;Tang Y;Yang Z;Guo L;Yang S;
{Journal}: Medicine (Baltimore)
{Volume}: 103
{Issue}: 30
{Year}: 2024 Jul 26
{Factor}: 1.817
{DOI}: 10.1097/MD.0000000000039150
{Abstract}: <B>BACKGROUND: </B>Hyalinizing clear cell carcinoma (HCCC) of the salivary glands is a rare low-grade malignant tumor. This type of tumor is particularly uncommon in the sublingual glands.<BR><B>METHODS: </B>A 57-year-old female with a mass on the left side of the floor of the mouth that had been present for 2 months. The computed tomography scan of the neck revealed a nodular abnormal density shadow in the left sublingual area, measuring approximately 2.6 cm × 1.9 cm.<BR><B>METHODS: </B>Primary HCCC of the sublingual gland.<BR><B>METHODS: </B>The patient underwent surgical treatment and reconstruction using a left anterolateral femoral free flap, which showed immunohistochemical positivity for CK 5/6, CK 7, CK (AE1/AE3), and Ki-67 (<5%), but negative for SMA and S-100.<BR><B>RESULTS: </B>No recurrence was observed during the 12-month postoperative follow-up period.<BR><B>CONCLUSIONS: </B>The absence of characteristic clinical manifestations makes HCCC highly susceptible to misdiagnoses. This case presents a rare instance of HCCC in the sublingual gland, providing a reference for the clinical diagnosis and treatment of the disease.