PDF(Pubmed)
Abstract：
BACKGROUND: Endocrine-disrupting chemicals (EDCs) are pervasive in everyday environments. The impacts of these chemicals, along with EDC-related lifestyle and dietary habits on neurocognitive function, are not well understood.
METHODS: The Chang Gung Community Medicine Research Center conducted a cross-sectional study involving 887 participants. From this initial cohort, 120 individuals were selected based on their EDC exposure scores for detailed analysis. Among these, 67 participants aged 55 years or older were further chosen to undergo cognitive impairment assessments using the Ascertain Dementia-8 (AD-8) questionnaire.
RESULTS: These 67 older participants did not significantly differ in age, albuminuria, or estimated glomerular filtration rate compared to those with lower impairment scores. This study revealed that mono-(2-ethylhexyl) phthalate (MEHP) levels (8.511 vs. 6.432 µg/g creatinine, p = 0.038) were associated with greater risk of cognitive impairment (AD-8 ≥ 2). Statistical models adjusting for age, gender, and diabetes indicated that MEHP levels positively correlated with AD-8 scores, achieving statistical significance in more comprehensive models (β ± SE: 0.160 ± 0.076, p = 0.042). Logistic regression analysis underscored a significant positive association between high MEHP levels and higher AD-8 scores (odds ratio: 1.217, p = 0.006). Receiver operating characteristic curves highlighted the association of high MEHP levels and EDC exposure scores for significant cognitive impairment, with areas under the curve of 66.3% and 66.6%, respectively.
CONCLUSIONS: Exposure to EDCs, specifically di-(2-ethylhexyl) phthalate, the precursor to MEHP, may be associated with neurocognitive impairment in middle-aged and older adults.
METHODS: The Chang Gung Community Medicine Research Center conducted a cross-sectional study involving 887 participants. From this initial cohort, 120 individuals were selected based on their EDC exposure scores for detailed analysis. Among these, 67 participants aged 55 years or older were further chosen to undergo cognitive impairment assessments using the Ascertain Dementia-8 (AD-8) questionnaire.
RESULTS: These 67 older participants did not significantly differ in age, albuminuria, or estimated glomerular filtration rate compared to those with lower impairment scores. This study revealed that mono-(2-ethylhexyl) phthalate (MEHP) levels (8.511 vs. 6.432 µg/g creatinine, p = 0.038) were associated with greater risk of cognitive impairment (AD-8 ≥ 2). Statistical models adjusting for age, gender, and diabetes indicated that MEHP levels positively correlated with AD-8 scores, achieving statistical significance in more comprehensive models (β ± SE: 0.160 ± 0.076, p = 0.042). Logistic regression analysis underscored a significant positive association between high MEHP levels and higher AD-8 scores (odds ratio: 1.217, p = 0.006). Receiver operating characteristic curves highlighted the association of high MEHP levels and EDC exposure scores for significant cognitive impairment, with areas under the curve of 66.3% and 66.6%, respectively.
CONCLUSIONS: Exposure to EDCs, specifically di-(2-ethylhexyl) phthalate, the precursor to MEHP, may be associated with neurocognitive impairment in middle-aged and older adults.
摘要：
背景：内分泌干扰化学物质（EDCs）在日常环境中普遍存在。这些化学物质的影响，以及与EDC相关的生活方式和饮食习惯对神经认知功能的影响，不是很了解。
方法：长贡社区医学研究中心进行了一项涉及887名参与者的横断面研究。从最初的队列中，根据他们的EDC暴露分数选择120个个体进行详细分析。其中,使用AscertainDementia-8（AD-8）问卷进一步选择67名55岁或以上的参与者进行认知障碍评估。
结果：这67名年龄较大的参与者在年龄上没有显著差异，白蛋白尿,或估计的肾小球滤过率与受损评分较低的肾小球滤过率相比。这项研究表明，邻苯二甲酸单(2-乙基己基)酯(MEHP)水平(8.511vs.6.432微克/克肌酐，p=0.038)与更高的认知障碍风险(AD-8≥2)相关。根据年龄调整的统计模型，性别,和糖尿病表明MEHP水平与AD-8评分呈正相关，在更全面的模型中达到统计学意义(β±SE：0.160±0.076，p=0.042)。Logistic回归分析强调了高MEHP水平和较高AD-8评分之间的显著正相关(比值比:1.217,p=0.006)。受试者工作特征曲线突出了高MEHP水平和EDC暴露评分与显著认知障碍的相关性，曲线下面积分别为66.3%和66.6%,分别。
结论：暴露于EDCs，特别是邻苯二甲酸二(2-乙基己基)酯，MEHP的前身，可能与中老年人的神经认知障碍有关。
方法：长贡社区医学研究中心进行了一项涉及887名参与者的横断面研究。从最初的队列中，根据他们的EDC暴露分数选择120个个体进行详细分析。其中,使用AscertainDementia-8（AD-8）问卷进一步选择67名55岁或以上的参与者进行认知障碍评估。
结果：这67名年龄较大的参与者在年龄上没有显著差异，白蛋白尿,或估计的肾小球滤过率与受损评分较低的肾小球滤过率相比。这项研究表明，邻苯二甲酸单(2-乙基己基)酯(MEHP)水平(8.511vs.6.432微克/克肌酐，p=0.038)与更高的认知障碍风险(AD-8≥2)相关。根据年龄调整的统计模型，性别,和糖尿病表明MEHP水平与AD-8评分呈正相关，在更全面的模型中达到统计学意义(β±SE：0.160±0.076，p=0.042)。Logistic回归分析强调了高MEHP水平和较高AD-8评分之间的显著正相关(比值比:1.217,p=0.006)。受试者工作特征曲线突出了高MEHP水平和EDC暴露评分与显著认知障碍的相关性，曲线下面积分别为66.3%和66.6%,分别。
结论：暴露于EDCs，特别是邻苯二甲酸二(2-乙基己基)酯，MEHP的前身，可能与中老年人的神经认知障碍有关。
