UNASSIGNED: This was a randomized controlled non-inferiority trial involving 108 children with plaque-induced gingivitis who were randomly assigned to three groups of 36 children each: Group A, AA + TA mouthwash; Group B, CHX mouthwash; and Group C, placebo mouthwash. Gingival index and plaque index were recorded at baseline, 7th and 21st day. RT-PCR was employed to determine the bacterial counts of each plaque sample at baseline and after 21 days.
UNASSIGNED: All three groups exhibited a gradual and significant reduction in both gingival and plaque scores from baseline to days 7 and 21. However, the placebo group did not demonstrate a significant difference in scores between days 7 and 21. Furthermore, a significant reduction in bacterial counts of P. gingivalis and T. forsythia was observed in the groups receiving CHX and AA + TA mouthwash after 21 days of intervention compared to the placebo group.
UNASSIGNED: AA + TA mouthwash demonstrated non-inferiority in anti-gingivitis and anti-plaque properties compared to CHX, suggesting its potential suitability as an alternative to CHX when used in conjunction with mechanical plaque control measures.
■这是一项随机对照非劣效性试验,涉及108名牙菌斑诱发牙龈炎儿童,随机分为三组,每组36名儿童:A组,AA+TA漱口水;B组,CHX漱口水;和C组,安慰剂漱口水.记录基线时的牙龈指数和菌斑指数,第7天和第21天在基线和21天后,采用RT-PCR来确定每个噬斑样品的细菌计数。
■从基线到第7天和第21天,所有三组的牙龈和牙菌斑评分均逐渐显着降低。然而,安慰剂组在第7天至第21天的评分无显著差异.此外,与安慰剂组相比,干预21天后接受CHX和AA+TA漱口水的组牙龈卟啉单胞菌和连翘T.
■与CHX相比,AA+TA漱口水在抗牙龈炎和抗牙斑特性方面表现出非劣效性,提示当与机械斑块控制措施结合使用时,它可能适合作为CHX的替代品。