PDF(Pubmed)
Abstract：
UNASSIGNED: Achyranthes aspera (Apamarga) and Trachyspermum ammi (Ajwain) have been used in many clinical conditions, and it displays valuable properties as an alternative to Chlorhexidine (CHX) in the management of gingivitis. Therefore, this study aims to assess the effect of Achyranthes aspera and Trachyspermum ammi (AA + TA) based herbal mouthwash, 0.2 % CHX, and placebo mouthwash on gingival health, plaque control and antibacterial activity against specific periodontal pathogens (Porphyromonas gingivalis and Tannerella forsythia) using quantitative real-time PCR (RT-PCR).
UNASSIGNED: This was a randomized controlled non-inferiority trial involving 108 children with plaque-induced gingivitis who were randomly assigned to three groups of 36 children each: Group A, AA + TA mouthwash; Group B, CHX mouthwash; and Group C, placebo mouthwash. Gingival index and plaque index were recorded at baseline, 7th and 21st day. RT-PCR was employed to determine the bacterial counts of each plaque sample at baseline and after 21 days.
UNASSIGNED: All three groups exhibited a gradual and significant reduction in both gingival and plaque scores from baseline to days 7 and 21. However, the placebo group did not demonstrate a significant difference in scores between days 7 and 21. Furthermore, a significant reduction in bacterial counts of P. gingivalis and T. forsythia was observed in the groups receiving CHX and AA + TA mouthwash after 21 days of intervention compared to the placebo group.
UNASSIGNED: AA + TA mouthwash demonstrated non-inferiority in anti-gingivitis and anti-plaque properties compared to CHX, suggesting its potential suitability as an alternative to CHX when used in conjunction with mechanical plaque control measures.
UNASSIGNED: This was a randomized controlled non-inferiority trial involving 108 children with plaque-induced gingivitis who were randomly assigned to three groups of 36 children each: Group A, AA + TA mouthwash; Group B, CHX mouthwash; and Group C, placebo mouthwash. Gingival index and plaque index were recorded at baseline, 7th and 21st day. RT-PCR was employed to determine the bacterial counts of each plaque sample at baseline and after 21 days.
UNASSIGNED: All three groups exhibited a gradual and significant reduction in both gingival and plaque scores from baseline to days 7 and 21. However, the placebo group did not demonstrate a significant difference in scores between days 7 and 21. Furthermore, a significant reduction in bacterial counts of P. gingivalis and T. forsythia was observed in the groups receiving CHX and AA + TA mouthwash after 21 days of intervention compared to the placebo group.
UNASSIGNED: AA + TA mouthwash demonstrated non-inferiority in anti-gingivitis and anti-plaque properties compared to CHX, suggesting its potential suitability as an alternative to CHX when used in conjunction with mechanical plaque control measures.
摘要：
■牛膝（Apamarga）和Trachysperammi（Ajwain）已在许多临床条件下使用，它显示有价值的特性，可替代氯己定（CHX）治疗牙龈炎。因此,这项研究旨在评估以牛膝和茶精（AA+TA）为基础的草药漱口水的效果，0.2%CHX,和安慰剂漱口水对牙龈健康的影响，使用定量实时PCR（RT-PCR）对特定牙周病原体（牙龈卟啉单胞菌和连翘膜）的菌斑控制和抗菌活性。
■这是一项随机对照非劣效性试验，涉及108名牙菌斑诱发牙龈炎儿童，随机分为三组，每组36名儿童：A组，AA+TA漱口水；B组，CHX漱口水；和C组，安慰剂漱口水.记录基线时的牙龈指数和菌斑指数，第7天和第21天在基线和21天后,采用RT-PCR来确定每个噬斑样品的细菌计数。
■从基线到第7天和第21天，所有三组的牙龈和牙菌斑评分均逐渐显着降低。然而,安慰剂组在第7天至第21天的评分无显著差异.此外，与安慰剂组相比,干预21天后接受CHX和AA+TA漱口水的组牙龈卟啉单胞菌和连翘T.
■与CHX相比，AA+TA漱口水在抗牙龈炎和抗牙斑特性方面表现出非劣效性，提示当与机械斑块控制措施结合使用时，它可能适合作为CHX的替代品。
■这是一项随机对照非劣效性试验，涉及108名牙菌斑诱发牙龈炎儿童，随机分为三组，每组36名儿童：A组，AA+TA漱口水；B组，CHX漱口水；和C组，安慰剂漱口水.记录基线时的牙龈指数和菌斑指数，第7天和第21天在基线和21天后,采用RT-PCR来确定每个噬斑样品的细菌计数。
■从基线到第7天和第21天，所有三组的牙龈和牙菌斑评分均逐渐显着降低。然而,安慰剂组在第7天至第21天的评分无显著差异.此外，与安慰剂组相比,干预21天后接受CHX和AA+TA漱口水的组牙龈卟啉单胞菌和连翘T.
■与CHX相比，AA+TA漱口水在抗牙龈炎和抗牙斑特性方面表现出非劣效性，提示当与机械斑块控制措施结合使用时，它可能适合作为CHX的替代品。
