PDF(Pubmed)
Abstract：
UNASSIGNED: Healing of bum wounds is commonly associated with many complications. Every year various new repair materials are developed and experimentally used for treating burn wounds. Humans with diabetes mellitus usually suffer from chronic wound healing. Vascular, neuropathic, immune function, and biochemical abnormalities each contribute to the altered tissue repair. One underlying factor that accompanies all diabetic ulcerations is poor vascular flow, a circumstance that impedes proper wound healing. Numerous studies have highlighted the importance of adequate vascular sufficiency and vessel proliferation in tissue repair and the lack thereof in diabetic wound healing. Other studies have looked at whether disarrayed capillary remodeling and maturation of vessels might play a role in impaired diabetic wound healing.
UNASSIGNED: This investigation has been planned to report the influence of treatment with a mixture of both the powder of pomegranate peel (PP) accompanied with an autologous bone marrow (BM) on the cure of burn injuries in experimentally induced diabetic rabbits.
UNASSIGNED: Alloxan monohydrate has been applied to create diabetes in 50 rabbits. Then in each rabbit, two deep second-degree burn wounds were experimentally created. The animals were then divided randomly into 5 treatment sections: non-treatment controls (C1), treated with an available commercial powder for wound (C2), treatment with powder of PP, treatment with alone BM, and the final group treated with PP powder with bone marrow (PPBM). The speed of wound closure and the histopathological changes during healing were measured. The levels of the biomarkers of rabbit platelet-derived growth factor AA (PDGF-AA) and rabbit protease-activated receptor 1 (PAR-1) were measured on days 0, 4, 8, and 12.
UNASSIGNED: Wound healing was markedly more rapid in all the treatment groups versus the control non-treated group. Interestingly, a rapid wound cure was significantly observed in the PPBM group versus the other treatment ones. The histological assessment clarified a significant elevation in the fibroblast and collagen scores in the PPBM group versus the other sections. In addition, there were significant increases in the serum levels of the biomarkers PDGF-AA and PAR-1 among groups.
UNASSIGNED: Dependent on the results of current research, it can be concluded that both PP powder with BM PPBM significantly accelerate the healing process of burn wounds in experimentally induced diabetic rabbits.
UNASSIGNED: This investigation has been planned to report the influence of treatment with a mixture of both the powder of pomegranate peel (PP) accompanied with an autologous bone marrow (BM) on the cure of burn injuries in experimentally induced diabetic rabbits.
UNASSIGNED: Alloxan monohydrate has been applied to create diabetes in 50 rabbits. Then in each rabbit, two deep second-degree burn wounds were experimentally created. The animals were then divided randomly into 5 treatment sections: non-treatment controls (C1), treated with an available commercial powder for wound (C2), treatment with powder of PP, treatment with alone BM, and the final group treated with PP powder with bone marrow (PPBM). The speed of wound closure and the histopathological changes during healing were measured. The levels of the biomarkers of rabbit platelet-derived growth factor AA (PDGF-AA) and rabbit protease-activated receptor 1 (PAR-1) were measured on days 0, 4, 8, and 12.
UNASSIGNED: Wound healing was markedly more rapid in all the treatment groups versus the control non-treated group. Interestingly, a rapid wound cure was significantly observed in the PPBM group versus the other treatment ones. The histological assessment clarified a significant elevation in the fibroblast and collagen scores in the PPBM group versus the other sections. In addition, there were significant increases in the serum levels of the biomarkers PDGF-AA and PAR-1 among groups.
UNASSIGNED: Dependent on the results of current research, it can be concluded that both PP powder with BM PPBM significantly accelerate the healing process of burn wounds in experimentally induced diabetic rabbits.
摘要：
■烧伤的愈合通常与许多并发症有关。每年都会开发出各种新的修复材料，并在实验上用于治疗烧伤伤口。患有糖尿病的人通常遭受慢性伤口愈合。血管,神经病,免疫功能，和生化异常都有助于改变组织修复。伴随所有糖尿病溃疡的一个潜在因素是血管流动不良，阻碍伤口正常愈合的情况。许多研究已经强调了组织修复中足够的血管充足性和血管增殖的重要性以及在糖尿病伤口愈合中缺乏血管的重要性。其他研究已经研究了受损的毛细血管重塑和血管成熟是否可能在受损的糖尿病伤口愈合中起作用。
■这项研究计划报道石榴皮（PP）粉末和自体骨髓（BM）的混合物对烧伤治疗的影响实验诱发的糖尿病兔。
■四氧嘧啶一水合物已用于在50只兔子中产生糖尿病。然后在每只兔子中，实验创造了两个深二度烧伤伤口。然后将动物随机分为5个治疗部分：非治疗对照（C1），用可用的商业伤口粉末处理（C2），用PP粉末处理，单独使用BM治疗，最后一组用带有骨髓的PP粉末(PPBM)处理。测量伤口闭合的速度和愈合过程中的组织病理学变化。在第0、4、8和12天测量兔血小板衍生生长因子AA（PDGF-AA）和兔蛋白酶激活受体1（PAR-1）的生物标志物水平。
与对照非治疗组相比,所有治疗组的伤口愈合明显更快。有趣的是,与其他治疗组相比，在PPBM组中观察到了快速的伤口治愈。组织学评估澄清了PPBM组的成纤维细胞和胶原评分相对于其他切片的显著升高。此外,各组间血清生物标志物PDGF-AA和PAR-1水平显著升高.
■根据当前研究的结果，可以得出结论，PP粉末与BMPPBM均显着加速了实验性糖尿病兔烧伤创面的愈合过程。
■这项研究计划报道石榴皮（PP）粉末和自体骨髓（BM）的混合物对烧伤治疗的影响实验诱发的糖尿病兔。
■四氧嘧啶一水合物已用于在50只兔子中产生糖尿病。然后在每只兔子中，实验创造了两个深二度烧伤伤口。然后将动物随机分为5个治疗部分：非治疗对照（C1），用可用的商业伤口粉末处理（C2），用PP粉末处理，单独使用BM治疗，最后一组用带有骨髓的PP粉末(PPBM)处理。测量伤口闭合的速度和愈合过程中的组织病理学变化。在第0、4、8和12天测量兔血小板衍生生长因子AA（PDGF-AA）和兔蛋白酶激活受体1（PAR-1）的生物标志物水平。
与对照非治疗组相比,所有治疗组的伤口愈合明显更快。有趣的是,与其他治疗组相比，在PPBM组中观察到了快速的伤口治愈。组织学评估澄清了PPBM组的成纤维细胞和胶原评分相对于其他切片的显著升高。此外,各组间血清生物标志物PDGF-AA和PAR-1水平显著升高.
■根据当前研究的结果，可以得出结论，PP粉末与BMPPBM均显着加速了实验性糖尿病兔烧伤创面的愈合过程。
