PDF(Pubmed)
Abstract：
Our previous clinical metabolomics study illustrated that energy metabolism disorder is an underlying pathogenesis mechanism for the development of alcoholic liver disease (ALD). Supplementation of nicotinamide (NAM), the precursor of nicotinamide adenine dinucleotide (NAD+), may restore the energy metabolism homeostasis of ALD and thus serves as potential therapeutics to treat ALD. In this bedside-to-bench study, the protective effect of NAM against ALD was investigated by using the NIAAA mice model (chronic-plus-binge ethanol), and the liver regeneration boosting capability of NAM was evaluated by the partial hepatectomy mice model. Our results showed that NAM supplements not only protected the liver from alcohol-induced injury and improved alcohol-induced mitochondrial structure and function change, but also boosted liver regeneration in postpartial hepatectomy mice by increasing liver NAD+ content. These findings suggested that NAM, a water-soluble form of vitamin B3, can promote liver regeneration and improves liver function by alleviating alcohol-induced energy metabolism disorder.
摘要：
我们先前的临床代谢组学研究表明，能量代谢障碍是酒精性肝病（ALD）发展的潜在发病机制。补充烟酰胺（NAM），烟酰胺腺嘌呤二核苷酸（NAD+）的前体，可以恢复ALD的能量代谢稳态，因此可以作为治疗ALD的潜在治疗剂。在这个床边到长凳的研究中，NAM对ALD的保护作用通过使用NIAAA小鼠模型（慢性加暴饮暴食乙醇），并通过部分肝切除小鼠模型评估NAM的肝再生促进能力。我们的结果表明，NAM补充剂不仅可以保护肝脏免受酒精引起的损伤，而且可以改善酒精引起的线粒体结构和功能变化。但也通过增加肝脏NAD+含量促进部分肝切除术后小鼠的肝脏再生。这些发现表明，不结盟运动，维生素B3的水溶性形式，可以通过缓解酒精引起的能量代谢障碍来促进肝脏再生和改善肝功能。
