PDF(Pubmed)
Abstract：
UNASSIGNED: Chronic Rhinosinusitis (CRS) is a common condition causing a significant worldwide burden, affecting 5%-12% of the general population. CRS is classified into type 2 and non-type 2 disease based on endotype dominance. Type 2 inflammation is distinguished by the presence of IL-4, IL-5, and IL-13 cytokines, along with eosinophil and mast cell activation and recruitment. Evidence of type 2 inflammation is ascertained by tissue eosinophil count >10/high-power field (HPF) or serum eosinophil >250 cells/mcL or total immunoglobulin E (IgE) > 100 IU/ml.
UNASSIGNED: To investigate the prevalence and characteristics of type 2 inflammation in patients who presented with nasal polyps and underwent Endoscopic Sinus Surgery (ESS) in Saudi Arabia.
UNASSIGNED: A retrospective cross-sectional Study.
UNASSIGNED: This study was conducted among patients who presented with nasal polyps and underwent ESS at King Saud University Medical City (KSUMC) from 2015 to 2020. Patients with nasal/sinus diseases other than Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) were excluded. Demographic data, olfaction status, and co-morbidities were collected, and radiological images were evaluated. Type 2-CRS was determined by meeting at least one of three predictor criteria (blood eosinophils ≥250 cells/mcL, tissue eosinophils ≥10/HPF, or total IgE levels ≥100 IU/ml). Blood parameters and histopathologic analysis were obtained for each patient.
UNASSIGNED: Of the 381 patients included in the study, the prevalence of type 2-CRS, based on the EPOS2020 criteria, was 99.7% in our population. Among these patients, 47.5% had hyposmia, 38.8% had anosmia, and 13.6% had normal olfaction. The most prevalent co-morbidity was allergic rhinitis, followed by bronchial asthma.
UNASSIGNED: This study aimed to determine the prevalence of type 2 inflammation among patients Diagnosed with CRSwNP and underwent ESS in Saudi Arabia. The results showed a prevalence of 99.7%, indicating that almost all recorded patients with CRSwNP in our population had type 2 inflammation.
UNASSIGNED: To investigate the prevalence and characteristics of type 2 inflammation in patients who presented with nasal polyps and underwent Endoscopic Sinus Surgery (ESS) in Saudi Arabia.
UNASSIGNED: A retrospective cross-sectional Study.
UNASSIGNED: This study was conducted among patients who presented with nasal polyps and underwent ESS at King Saud University Medical City (KSUMC) from 2015 to 2020. Patients with nasal/sinus diseases other than Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) were excluded. Demographic data, olfaction status, and co-morbidities were collected, and radiological images were evaluated. Type 2-CRS was determined by meeting at least one of three predictor criteria (blood eosinophils ≥250 cells/mcL, tissue eosinophils ≥10/HPF, or total IgE levels ≥100 IU/ml). Blood parameters and histopathologic analysis were obtained for each patient.
UNASSIGNED: Of the 381 patients included in the study, the prevalence of type 2-CRS, based on the EPOS2020 criteria, was 99.7% in our population. Among these patients, 47.5% had hyposmia, 38.8% had anosmia, and 13.6% had normal olfaction. The most prevalent co-morbidity was allergic rhinitis, followed by bronchial asthma.
UNASSIGNED: This study aimed to determine the prevalence of type 2 inflammation among patients Diagnosed with CRSwNP and underwent ESS in Saudi Arabia. The results showed a prevalence of 99.7%, indicating that almost all recorded patients with CRSwNP in our population had type 2 inflammation.
摘要：
■慢性鼻-鼻窦炎（CRS）是一种常见的疾病，在全球范围内造成了巨大的负担，影响5%-12%的普通人群。CRS基于内型优势分为2型和非2型疾病。2型炎症通过IL-4，IL-5和IL-13细胞因子的存在来区分。随着嗜酸性粒细胞和肥大细胞的激活和募集。通过组织嗜酸性粒细胞计数>10/高倍视野（HPF）或血清嗜酸性粒细胞>250个细胞/mcL或总免疫球蛋白E（IgE）>100IU/ml来确定2型炎症的证据。
■目的调查沙特阿拉伯鼻息肉并接受鼻内镜鼻窦手术（ESS）的2型炎症的患病率和特征。
■回顾性横断面研究。
■这项研究是在2015年至2020年在沙特国王大学医学城（KSUMC）接受鼻息肉治疗的患者中进行的。除慢性鼻-鼻窦炎伴鼻息肉(CRSwNP)以外的鼻/鼻窦疾病患者被排除。人口统计数据,嗅觉状态,收集了合并症，和放射学图像进行了评估。通过满足三个预测标准中的至少一个来确定2型CRS（血液嗜酸性粒细胞≥250个细胞/mcL，组织嗜酸性粒细胞≥10/HPF，或总IgE水平≥100IU/ml)。获得每位患者的血液参数和组织病理学分析。
■在纳入研究的381名患者中，2型CRS的患病率，根据EPOS2020标准，在我们的人口中是99.7%。在这些患者中,47.5％的人患有食欲不振，38.8%有嗅觉缺失,13.6%的患者嗅觉正常。最常见的合并症是过敏性鼻炎，其次是支气管哮喘。
■本研究旨在确定在沙特阿拉伯诊断为CRSwNP并接受ESS的患者中2型炎症的患病率。结果显示患病率为99.7%,表明我们人群中几乎所有记录的CRSwNP患者都有2型炎症.
■目的调查沙特阿拉伯鼻息肉并接受鼻内镜鼻窦手术（ESS）的2型炎症的患病率和特征。
■回顾性横断面研究。
■这项研究是在2015年至2020年在沙特国王大学医学城（KSUMC）接受鼻息肉治疗的患者中进行的。除慢性鼻-鼻窦炎伴鼻息肉(CRSwNP)以外的鼻/鼻窦疾病患者被排除。人口统计数据,嗅觉状态,收集了合并症，和放射学图像进行了评估。通过满足三个预测标准中的至少一个来确定2型CRS（血液嗜酸性粒细胞≥250个细胞/mcL，组织嗜酸性粒细胞≥10/HPF，或总IgE水平≥100IU/ml)。获得每位患者的血液参数和组织病理学分析。
■在纳入研究的381名患者中，2型CRS的患病率，根据EPOS2020标准，在我们的人口中是99.7%。在这些患者中,47.5％的人患有食欲不振，38.8%有嗅觉缺失,13.6%的患者嗅觉正常。最常见的合并症是过敏性鼻炎，其次是支气管哮喘。
■本研究旨在确定在沙特阿拉伯诊断为CRSwNP并接受ESS的患者中2型炎症的患病率。结果显示患病率为99.7%,表明我们人群中几乎所有记录的CRSwNP患者都有2型炎症.
