PDF(Pubmed)
Abstract：
Breast cancer (BC) is a major malignant tumor in females and the incidence rate of BC has increased worldwide in recent years. N6‑methyladenosine (m6A) is a methylation modification that occurs extensively in eukaryotic RNA. The abnormal expression of m6A and related regulatory proteins can activate or inhibit certain signal pathways or oncogenes, thus affecting the proliferation, metastasis and prognosis of BC. Numerous studies have shown that m6A regulator disorder exists in BC, and this disorder can be reversed. Therefore, m6A is predicted as a potential therapeutic target for BC. However, the molecular mechanism of m6A RNA methylation regulating the occurrence and development of BC has not been comprehensively elucidated. In this review article, the functions of various m6A regulators and the specific mechanisms of certain regulators of the progress of BC were summarized. Furthermore, the dual role of RNA methylation in tumor progression was discussed, concluding that RNA methylation can not only lead to tumorigenesis but at times give rise to inhibition of tumor formation. In addition, further comprehensive analysis on mechanisms of m6A regulators in BC is conducive to screening effective potential targets and formulating targeted treatment strategies, which will provide new methods for the prevention and treatment of BC.
摘要：
乳腺癌（BC）是女性的主要恶性肿瘤，近年来在全球范围内的发病率有所增加。N6-甲基腺苷（m6A）是一种甲基化修饰，广泛存在于真核RNA中。m6A及相关调控蛋白的异常表达可激活或抑制某些信号通路或癌基因,从而影响扩散，BC的转移和预后。大量研究表明，m6A调节障碍存在于BC，这种紊乱是可以逆转的。因此,m6A被预测为BC的潜在治疗靶标。然而,m6ARNA甲基化调控BC发生发展的分子机制尚未全面阐明。在这篇评论文章中，总结了各种m6A调节子的功能和某些调节子对BC进展的具体作用机制。此外，讨论了RNA甲基化在肿瘤进展中的双重作用，结论RNA甲基化不仅可以导致肿瘤发生，而且有时会抑制肿瘤的形成。此外,进一步全面分析BC中m6A调控因子的作用机制,有利于筛选有效的潜在靶点,制定针对性的治疗策略,这将为BC的预防和治疗提供新的方法。
