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Abstract：
OBJECTIVE: To analyze the clinicopathological features of schistosomal and non-schistosomal colorectal cancer in Central China and compare them with other areas of the Yangtze River Basin.
METHODS: The 501 cases of colorectal cancer (CRC) were retrospectively analyzed from 2020 to 2022. They were divided into two groups: 406 cases of colorectal cancer without schistosomiasis (CRC-NS) and 95 cases of colorectal cancer with schistosomiasis (CRC-S).The clinicopathological characteristics included the distribution of schistosomiasis eggs, patient age, sex, tumor differentiation, lymph node metastasis, and clinical stage. By retrieving the database, this study compared the clinicopathological differences of colorectal cancer with schistosomiasis in other areas of the Yangtze River basin.
RESULTS: The cases of colorectal cancer with schistosomiasis accounted for 18.9%(95/501) in the study. The patients of CRC-S were older than the patients of CRC-NS (P = 0.002, P < 0.05). There was a statistical difference in the location of occurrence (P = 0.000, P < 0.05) between the two groups. There were no significant differences between CRC-S and CRC-NS in other clinicopathological features, such as sex (P = 0.054), Type(P = 0.242), histological type(P = 0.654), infiltrative depth(P = 0.811), differentiation(P = 0.837), lymph node metastasis(P = 0.574), intravascular tumor thrombus(P = 0.698), T stage(P = 0.354). In other areas of the Yangtze River Basin, there were statistical differences in the age of occurrence and T stage (P < 0.05) between colorectal cancer with schistosomiasis and non-schistosomal colorectal cancer.
CONCLUSIONS: In Central China, colorectal cancer with chronic schistosomiasis infection occurs more in the rectum and sigmoid colon. It is more common in individuals over 60 years old, consistent with the findings in the Yangtze River Basin. Additionally, schistosomal colorectal cancer had a higher T stage in the Yangtze River Basin. This may be related to the malignant biological behavior of colorectal cancer and could result in a relatively poor prognosis. Therefore, the elderly population in schistosomiasis endemic areas should pay more attention to early screening and tumor prevention.
METHODS: The 501 cases of colorectal cancer (CRC) were retrospectively analyzed from 2020 to 2022. They were divided into two groups: 406 cases of colorectal cancer without schistosomiasis (CRC-NS) and 95 cases of colorectal cancer with schistosomiasis (CRC-S).The clinicopathological characteristics included the distribution of schistosomiasis eggs, patient age, sex, tumor differentiation, lymph node metastasis, and clinical stage. By retrieving the database, this study compared the clinicopathological differences of colorectal cancer with schistosomiasis in other areas of the Yangtze River basin.
RESULTS: The cases of colorectal cancer with schistosomiasis accounted for 18.9%(95/501) in the study. The patients of CRC-S were older than the patients of CRC-NS (P = 0.002, P < 0.05). There was a statistical difference in the location of occurrence (P = 0.000, P < 0.05) between the two groups. There were no significant differences between CRC-S and CRC-NS in other clinicopathological features, such as sex (P = 0.054), Type(P = 0.242), histological type(P = 0.654), infiltrative depth(P = 0.811), differentiation(P = 0.837), lymph node metastasis(P = 0.574), intravascular tumor thrombus(P = 0.698), T stage(P = 0.354). In other areas of the Yangtze River Basin, there were statistical differences in the age of occurrence and T stage (P < 0.05) between colorectal cancer with schistosomiasis and non-schistosomal colorectal cancer.
CONCLUSIONS: In Central China, colorectal cancer with chronic schistosomiasis infection occurs more in the rectum and sigmoid colon. It is more common in individuals over 60 years old, consistent with the findings in the Yangtze River Basin. Additionally, schistosomal colorectal cancer had a higher T stage in the Yangtze River Basin. This may be related to the malignant biological behavior of colorectal cancer and could result in a relatively poor prognosis. Therefore, the elderly population in schistosomiasis endemic areas should pay more attention to early screening and tumor prevention.
摘要：
目的：分析华中地区血吸虫和非血吸虫结直肠癌的临床病理特征，并与长江流域其他地区进行比较。
方法：回顾性分析2020-2022年501例结直肠癌患者的临床资料。将其分为两组：无血吸虫病的结直肠癌（CRC-NS）406例和有血吸虫病的结直肠癌（CRC-S）95例。临床病理特征包括血吸虫病卵的分布，患者年龄,性别,肿瘤分化，淋巴结转移,和临床分期。通过检索数据库，本研究比较了长江流域其他地区结直肠癌与血吸虫病的临床病理差异。
结果：结直肠癌合并血吸虫病的病例占18.9%(95/501)。CRC-S患者年龄大于CRC-NS患者(P=0.002,P<0.05)。两组发生部位差异有统计学意义(P=0.000,P<0.05)。CRC-S和CRC-NS在其他临床病理特征上无显著差异,如性别（P=0.054），类型(P=0.242),组织学类型（P=0.654），浸润深度(P=0.811),分化（P=0.837），淋巴结转移（P=0.574），血管内肿瘤血栓（P=0.698），T阶段(P=0.354)。在长江流域的其他地区，结直肠癌合并血吸虫病与非血吸虫病结直肠癌在发病年龄、T分期方面差异有统计学意义(P<0.05)。
结论：在华中地区，结直肠癌合并慢性血吸虫病感染多见于直肠和乙状结肠。它在60岁以上的人中更常见，与长江流域的研究结果一致。此外,长江流域血吸虫结直肠癌T分期较高。这可能与结直肠癌的恶性生物学行为有关，并可能导致相对较差的预后。因此,血吸虫病流行地区的老年人群应更加重视早期筛查和肿瘤预防。
方法：回顾性分析2020-2022年501例结直肠癌患者的临床资料。将其分为两组：无血吸虫病的结直肠癌（CRC-NS）406例和有血吸虫病的结直肠癌（CRC-S）95例。临床病理特征包括血吸虫病卵的分布，患者年龄,性别,肿瘤分化，淋巴结转移,和临床分期。通过检索数据库，本研究比较了长江流域其他地区结直肠癌与血吸虫病的临床病理差异。
结果：结直肠癌合并血吸虫病的病例占18.9%(95/501)。CRC-S患者年龄大于CRC-NS患者(P=0.002,P<0.05)。两组发生部位差异有统计学意义(P=0.000,P<0.05)。CRC-S和CRC-NS在其他临床病理特征上无显著差异,如性别（P=0.054），类型(P=0.242),组织学类型（P=0.654），浸润深度(P=0.811),分化（P=0.837），淋巴结转移（P=0.574），血管内肿瘤血栓（P=0.698），T阶段(P=0.354)。在长江流域的其他地区，结直肠癌合并血吸虫病与非血吸虫病结直肠癌在发病年龄、T分期方面差异有统计学意义(P<0.05)。
结论：在华中地区，结直肠癌合并慢性血吸虫病感染多见于直肠和乙状结肠。它在60岁以上的人中更常见，与长江流域的研究结果一致。此外,长江流域血吸虫结直肠癌T分期较高。这可能与结直肠癌的恶性生物学行为有关，并可能导致相对较差的预后。因此,血吸虫病流行地区的老年人群应更加重视早期筛查和肿瘤预防。
