METHODS: A prospective observational study was carried out in sub-Saharan migrants who were diagnosed with confirmed genitourinary schistosomiasis. A tailored protocol was applied, including Schistosoma serology, a specific urine LAMP tests for schistosomiasis and an ultrasound examination before treatment with praziquantel. A scheduled follow-up was performed at 3, 6 and 12 months to monitor treatment response, comparing patients carriers of Schistosoma hybrids with carriers of only genetically pure forms.
RESULTS: A total of 31 male patients from West Africa were included in the study with a mean age of 26.5 years. Twelve (38.7 %) of the patients were carriers of Schistosoma hybrids. As compared with patients infected with S. haematobium alone, hybrid carriers had lower haemoglobin levels (13.8 g/dL [SD 1.8] vs 14.8 g/dL [SD 1.4], p = 0.04), a greater frequency of hematuria (100 % vs 52.6 %, p = 0.005), a higher ultrasound score (2.64, SD 2.20 vs 0.89, SD 0.99; p = 0.02). However, the presence of hybrids did not result in differences in clinical and analytical responses after treatment.
CONCLUSIONS: The presence of Schistosoma hybrids seems to cause increased morbidity in infected individuals. However, it does not appear to result in differences in diagnostic tests or in clinical and analytical responses after treatment.
方法:对被确诊为泌尿生殖道血吸虫病的撒哈拉以南移民进行了一项前瞻性观察性研究。采用了量身定制的协议,包括血吸虫血清学,用吡喹酮治疗前进行血吸虫病的特定尿液LAMP检查和超声检查。在第3、6和12个月进行了预定的随访,以监测治疗反应,将血吸虫杂种的患者携带者与仅遗传纯形式的携带者进行比较。
结果:共有31名来自西非的男性患者被纳入研究,平均年龄为26.5岁。12例(38.7%)的患者是血吸虫杂种的携带者。与仅感染血吸虫的患者相比,杂种携带者的血红蛋白水平较低(13.8g/dL[SD1.8]对14.8g/dL[SD1.4],p=0.04),血尿的频率更高(100%对52.6%,p=0.005),超声评分较高(2.64,SD2.20vs0.89,SD0.99;p=0.02)。然而,杂交体的存在并未导致治疗后临床和分析应答的差异.
结论:血吸虫杂种的存在似乎导致感染个体发病率增加。然而,它似乎不会导致治疗后诊断测试或临床和分析反应的差异.