PDF(Pubmed)
Abstract：
In 2018 there was a large yellow fever outbreak in São Paulo, Brazil, with a high fatality rate. Yellow fever virus can cause, among other symptoms, hemorrhage and disseminated intravascular coagulation, indicating a role for endothelial cells in disease pathogenesis. Here, we conducted a case-control study and measured markers related to endothelial damage in plasma and its association with mortality. We found that angiopoietin 2 is strongly associated with a fatal outcome and could serve as a predictive marker for mortality. This could be used to monitor severe cases and provide care to improve disease outcome.
摘要：
2018年，圣保罗爆发了大规模的黄热病疫情，巴西,死亡率很高。黄热病病毒可以引起,在其他症状中，出血和弥散性血管内凝血，表明内皮细胞在疾病发病机制中的作用。这里,我们进行了一项病例对照研究,并测定了血浆中与内皮损伤相关的标志物及其与死亡率的关系.我们发现血管生成素2与致命结局密切相关，可以作为死亡率的预测指标。这可用于监测严重病例并提供护理以改善疾病结果。
