PDF(Pubmed)
Abstract：
UNASSIGNED: Cardiac dysfunction is a serious adverse effect of cancer therapies that can interfere with quality of life and impact long-term survival in patients with cancer. Hematopoietic cell transplantation is a potentially curative therapy for many advanced hematologic malignancies and bone marrow failure syndromes, however is associated with several short- and long-term adverse effects, including importantly, cardiovascular toxicities. The goal of this review article is to describe the cardiovascular events that may develop before, during, and after hematopoietic cell transplantation, review risk factors for short- and long-term cardiovascular toxicities, discuss approaches to cardiovascular risk stratification and evaluation, and highlight the research gaps in the consideration of cardiovascular disease in patients undergoing hematopoietic cell transplantation. Further understanding of cardiovascular events and the factors associated with cardiovascular disease will hopefully lead to novel interventions in managing and mitigating the significant long-term burden of late cardiovascular effects in transplant survivors.
摘要：
■心脏功能障碍是癌症治疗的严重不良反应，可干扰癌症患者的生活质量并影响长期生存。造血细胞移植是许多晚期血液系统恶性肿瘤和骨髓衰竭综合征的潜在治愈疗法，然而，与一些短期和长期的不良反应有关，包括重要的,心血管毒性。这篇综述文章的目的是描述以前可能发生的心血管事件，during,造血细胞移植后，回顾短期和长期心血管毒性的危险因素，讨论心血管危险分层和评估的方法，并强调了造血细胞移植患者在考虑心血管疾病方面的研究空白。对心血管事件和与心血管疾病相关的因素的进一步了解将有望导致新的干预措施，以管理和减轻移植幸存者晚期心血管影响的重大长期负担。
