METHODS: One hundred three patients with lumbar radicular pain were treated with a SNRB. Patient-reported outcome measures (PROMs) were assessed with the PROMIS-29 for 12 weeks (84 days) following the SNRB. Patients were stratified based on their pain reduction at the 14-day follow up as responders (≥ 30% pain reduction) and non-responders (< 30% pain reduction). Post-treatment duration was estimated with the Kaplan-Meier analysis with return to baseline as an event. A paired t-test was used to compare pre- and post-treatment responses at specific time intervals.
RESULTS: Forty-four percent (n = 45) of the patients were responders and showed significant improvement in all parameters throughout the 84-days follow-up, the exception was sleep that lost significance at day 70. The mean post-treatment duration among responders was 59 (52-67) days. Non-responders showed significant improvements in pain interference and pain intensity until day 35 and in ability for social participation until 21-day.
CONCLUSIONS: SNRB can improve pain intensity, pain interference, physical function, fatigue, anxiety, depression, sleep disturbance and the ability to participate in social roles.
方法:用SNRB治疗130例腰椎神经根性疼痛患者。SNRB后12周(84天)用PROMIS-29评估患者报告的结果测量(PROMs)。在14天的随访中,根据患者的疼痛减轻情况将患者分层为响应者(疼痛减轻≥30%)和非响应者(疼痛减轻<30%)。使用Kaplan-Meier分析估计治疗后持续时间,其中返回基线作为事件。使用配对t检验以特定的时间间隔比较治疗前和治疗后的反应。
结果:44%(n=45)的患者是应答者,在整个84天的随访中,所有参数均有显着改善。唯一的例外是在第70天失去意义的睡眠。应答者的平均治疗后持续时间为59(52-67)天。无反应者在第35天之前的疼痛干扰和疼痛强度以及在21天之前的社会参与能力方面显示出显着改善。
结论:SNRB可以改善疼痛强度,疼痛干扰,物理功能,疲劳,焦虑,抑郁症,睡眠障碍和参与社会角色的能力。