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Abstract：
Hand, foot, and mouth disease (HFMD) is a common infectious disease caused by enteroviruses. Coxsackievirus A6 (CV-A6)-associated HFMD has recently emerged as a predominant disease worldwide. Here, we describe five HFMD cases caused by CV-A6 in Japan from 2019 to 2022. All clinical courses were not severe and were self-limited, and the skin exanthema with vesicles differed from that in classical HFMD. Phylogenetic analysis showed that the major epidemic strain cluster of CV-A6 was formed independently in 2011, and our latest CV-A6 strains in Japan were detected within this cluster. The five cases described in this report indicate the recent shift in the predominant and continuous disease manifestation of CV-A6-associated HFMD.
摘要：
手,脚,口蹄疫(HFMD)是由肠道病毒引起的常见传染病。柯萨奇病毒A6（CV-A6）相关的手足口病最近已成为世界范围内的主要疾病。这里,我们描述了2019年至2022年日本由CV-A6引起的5例手足口病病例。所有临床病程均不严重，并且是自限的，有囊泡的皮肤出斑与经典手足口病不同。系统发育分析表明，CV-A6的主要流行菌株簇是在2011年独立形成的，并且在该簇内检测到了我们在日本最新的CV-A6菌株。本报告中描述的五例病例表明，CV-A6相关HFMD的主要和连续疾病表现最近发生了变化。
