PDF(Pubmed)
Abstract：
UNASSIGNED: Pathological scars, such as hypertrophic scars and keloids, are characterized by the proliferation of fibroblasts and the deposition of collagen that often cause pruritus, pain, and disfigurement. Due to their high incidence and deformity, pathological scars have resulted in severe physical and psychological trauma for patients. Intralesional injection of 5-fluorouracil (5-Fu) is a recommended option for treating pathological scars. However, the efficacy of 5-Fu injection was limited and unstable due to limited drug penetration and short retention time.
UNASSIGNED: Liposomes are promising carriers that have advantages, such as high biocompatibility, controlled release property, and enhanced clinical efficacy. Here, we constructed a transdermal 5-Fu-loaded liposome (5-Fu-Lip) to provide a more effective and safer modality to scar treatment.
UNASSIGNED: Compared to 5-Fu, 5-Fu-Lip showed superior ability in inhibiting primary keloid fibroblasts proliferation, migration, and collagen deposition, and also significantly inhibited human umbilical vein endothelial cells (HUVECs) proliferation and microvessel construction. In vivo experiments demonstrated that 5-Fu-Lip can significantly reduce the severity of hypertrophic scars in a rabbit ear wounding model.
UNASSIGNED: 5-Fu-Lip provides a promising strategy to improve drug efficacy, which has great potential in the treatment of pathological scars.
UNASSIGNED: Liposomes are promising carriers that have advantages, such as high biocompatibility, controlled release property, and enhanced clinical efficacy. Here, we constructed a transdermal 5-Fu-loaded liposome (5-Fu-Lip) to provide a more effective and safer modality to scar treatment.
UNASSIGNED: Compared to 5-Fu, 5-Fu-Lip showed superior ability in inhibiting primary keloid fibroblasts proliferation, migration, and collagen deposition, and also significantly inhibited human umbilical vein endothelial cells (HUVECs) proliferation and microvessel construction. In vivo experiments demonstrated that 5-Fu-Lip can significantly reduce the severity of hypertrophic scars in a rabbit ear wounding model.
UNASSIGNED: 5-Fu-Lip provides a promising strategy to improve drug efficacy, which has great potential in the treatment of pathological scars.
摘要：
■病理性疤痕，比如肥厚性疤痕和瘢痕疙瘩,以成纤维细胞的增殖和胶原蛋白的沉积为特征，通常会引起瘙痒，疼痛,和毁容。由于它们的高发病率和畸形，病理性疤痕给患者造成了严重的生理和心理创伤。病灶内注射5-氟尿嘧啶（5-Fu）是治疗病理性疤痕的推荐选择。然而,5-Fu注射液由于药物渗透受限和保留时间短，疗效有限且不稳定。
■脂质体是具有优势的有前途的载体，如高生物相容性，控释性质，提高临床疗效。这里,我们构建了一种经皮5-Fu负载脂质体(5-Fu-Lip),为瘢痕治疗提供了一种更有效、更安全的方法.
■与5-Fu相比，5-Fu-Lip在抑制原发性瘢痕疙瘩成纤维细胞增殖方面表现出优异的能力，迁移,和胶原蛋白沉积，并且还显着抑制人脐静脉内皮细胞（HUVECs）的增殖和微血管的构建。体内实验表明，5-Fu-Lip可以显着降低兔耳损伤模型中肥厚性瘢痕的严重程度。
■5-Fu-Lip提供了一种有希望的策略来提高药物疗效，在治疗病理性疤痕方面具有巨大潜力。
■脂质体是具有优势的有前途的载体，如高生物相容性，控释性质，提高临床疗效。这里,我们构建了一种经皮5-Fu负载脂质体(5-Fu-Lip),为瘢痕治疗提供了一种更有效、更安全的方法.
■与5-Fu相比，5-Fu-Lip在抑制原发性瘢痕疙瘩成纤维细胞增殖方面表现出优异的能力，迁移,和胶原蛋白沉积，并且还显着抑制人脐静脉内皮细胞（HUVECs）的增殖和微血管的构建。体内实验表明，5-Fu-Lip可以显着降低兔耳损伤模型中肥厚性瘢痕的严重程度。
■5-Fu-Lip提供了一种有希望的策略来提高药物疗效，在治疗病理性疤痕方面具有巨大潜力。
