PDF(Pubmed)
Abstract：
UNASSIGNED: Frailty is a significant public health issue facing aging societies and can be reduced by physical activity (PA), but the dose-response relationship between PA and frailty is not clear. This systematic review and dose-response meta-analysis aimed to assess the effect of PA on frailty in adults by aggregating data from observational studies.
UNASSIGNED: PubMed, Embase, Web of Science, Cochrane Library, Scopus, SAGE Reference Online, SinoMed, CINAHL and CNKI were retrieved for articles published before May 2024. After quality evaluation, data on PA and the risk of frailty were extracted. Stata/MP 17.0 was used for dose-response meta-analysis.
UNASSIGNED: A total of 15 articles were included, involving 34,754 participants, including 4250 subjects with frailty or pre-frailty. The consequence of the dose-response meta-analysis revealed that compared with those who were not active at all, a 22 % (95 % CI, 16 %-28 %) reduction in the risk of frailty in individuals with 11.25 MET h/week of cumulative activity and a 55 % (95 % CI, 44 %-63 %) reduction in the risk of frailty in those with 22.5 MET h/week of cumulative activity; for higher activity levels (36.75 MET h/week), the risk of frailty was reduced by 68 % (95 % CI, 58 %-76 %) and continued to be reduced as PA volum increased.
UNASSIGNED: There is a non-linear dose-response relationship between PA and frailty risk. Even small amounts of PA could reduce the risk of frailty. Meeting the minimum recommended PA target could reduce some risks, and doubling the recommended PA volumes could reduce most risks, which continue to increase as the volum of PA accumulates.
UNASSIGNED: PubMed, Embase, Web of Science, Cochrane Library, Scopus, SAGE Reference Online, SinoMed, CINAHL and CNKI were retrieved for articles published before May 2024. After quality evaluation, data on PA and the risk of frailty were extracted. Stata/MP 17.0 was used for dose-response meta-analysis.
UNASSIGNED: A total of 15 articles were included, involving 34,754 participants, including 4250 subjects with frailty or pre-frailty. The consequence of the dose-response meta-analysis revealed that compared with those who were not active at all, a 22 % (95 % CI, 16 %-28 %) reduction in the risk of frailty in individuals with 11.25 MET h/week of cumulative activity and a 55 % (95 % CI, 44 %-63 %) reduction in the risk of frailty in those with 22.5 MET h/week of cumulative activity; for higher activity levels (36.75 MET h/week), the risk of frailty was reduced by 68 % (95 % CI, 58 %-76 %) and continued to be reduced as PA volum increased.
UNASSIGNED: There is a non-linear dose-response relationship between PA and frailty risk. Even small amounts of PA could reduce the risk of frailty. Meeting the minimum recommended PA target could reduce some risks, and doubling the recommended PA volumes could reduce most risks, which continue to increase as the volum of PA accumulates.
摘要：
■脆弱是老龄化社会面临的重大公共卫生问题，可以通过体育锻炼（PA）来减少，但PA与虚弱之间的剂量-反应关系尚不清楚。本系统评价和剂量反应荟萃分析旨在通过汇总观察性研究的数据来评估PA对成人虚弱的影响。
■PubMed,Embase,WebofScience,科克伦图书馆,Scopus,SAGE在线参考,SinoMed,CINAHL和CNKI检索了2024年5月之前发表的文章。经过质量评估，提取PA和虚弱风险的数据.Stata/MP17.0用于剂量反应荟萃分析。
■共包括15篇文章，涉及34,754名参与者，包括4250名虚弱或预虚弱的受试者。剂量反应荟萃分析的结果显示，与那些根本不活跃的人相比，累积活动量为11.25METh/周的个体衰弱风险降低22%（95%CI，16%-28%），累积活动量为22.5METh/周的个体衰弱风险降低55%（95%CI，44%-63%）；对于较高的活动水平（36.75METh/周），衰弱风险降低了68%(95%CI,58%-76%),并随着PA体积的增加而持续降低.
■PA与虚弱风险之间存在非线性剂量反应关系。即使少量的PA也可以降低虚弱的风险。达到PA建议的最低目标可以降低一些风险，将推荐的PA容量增加一倍可以降低大多数风险，随着PA的体积积累，它继续增加。
■PubMed,Embase,WebofScience,科克伦图书馆,Scopus,SAGE在线参考,SinoMed,CINAHL和CNKI检索了2024年5月之前发表的文章。经过质量评估，提取PA和虚弱风险的数据.Stata/MP17.0用于剂量反应荟萃分析。
■共包括15篇文章，涉及34,754名参与者，包括4250名虚弱或预虚弱的受试者。剂量反应荟萃分析的结果显示，与那些根本不活跃的人相比，累积活动量为11.25METh/周的个体衰弱风险降低22%（95%CI，16%-28%），累积活动量为22.5METh/周的个体衰弱风险降低55%（95%CI，44%-63%）；对于较高的活动水平（36.75METh/周），衰弱风险降低了68%(95%CI,58%-76%),并随着PA体积的增加而持续降低.
■PA与虚弱风险之间存在非线性剂量反应关系。即使少量的PA也可以降低虚弱的风险。达到PA建议的最低目标可以降低一些风险，将推荐的PA容量增加一倍可以降低大多数风险，随着PA的体积积累，它继续增加。
