PDF(Pubmed)
Abstract：
UNASSIGNED: In this study, we investigated the blink reflex (BR) after simultaneous and asynchronous stimulation of two trigeminal nerve branches. The objective was to characterize the physiology of trigeminal and facial circuits.
UNASSIGNED: We performed three sets of experiments: recording BR response i. after supraorbital nerve stimulation (SON), after mental nerve stimulation (MN), and after simultaneous SON and MN stimulation (SON+MN) in 18 healthy individuals; ii. after MN (at an intensity eliciting BR response) preceding SON at various interstimulus intervals (ISIs) in seven healthy subjects; iii after MN (at sensory threshold) preceding SON at various ISIs. We compared the magnitudes of early and late responses.
UNASSIGNED: The R1 amplitude after simultaneous SON+MN stimulation was greater than responses after single stimulation of the same branches. After simultaneous stimulations, the R2 and R2c areas under the curve (AUC) were smaller than the arithmetic sums of R2 and R2c AUC obtained after single stimulations. The second experiment provided a recovery excitability curve. In the third step, we obtained facilitation of R1 and inhibition of late responses.
UNASSIGNED: The SON+MN stimulation caused an increased R1 circuit excitability compared to the arithmetic sum of the single stimulations; however, magnitudes of late responses did not potentiate. Thus, we have provided evidence for R1 circuit enhancement by simultaneous stimulation in humans, whereas modulation of late responses exhibited a recovery curve similar to that shown for paired SON stimulation.
UNASSIGNED: We performed three sets of experiments: recording BR response i. after supraorbital nerve stimulation (SON), after mental nerve stimulation (MN), and after simultaneous SON and MN stimulation (SON+MN) in 18 healthy individuals; ii. after MN (at an intensity eliciting BR response) preceding SON at various interstimulus intervals (ISIs) in seven healthy subjects; iii after MN (at sensory threshold) preceding SON at various ISIs. We compared the magnitudes of early and late responses.
UNASSIGNED: The R1 amplitude after simultaneous SON+MN stimulation was greater than responses after single stimulation of the same branches. After simultaneous stimulations, the R2 and R2c areas under the curve (AUC) were smaller than the arithmetic sums of R2 and R2c AUC obtained after single stimulations. The second experiment provided a recovery excitability curve. In the third step, we obtained facilitation of R1 and inhibition of late responses.
UNASSIGNED: The SON+MN stimulation caused an increased R1 circuit excitability compared to the arithmetic sum of the single stimulations; however, magnitudes of late responses did not potentiate. Thus, we have provided evidence for R1 circuit enhancement by simultaneous stimulation in humans, whereas modulation of late responses exhibited a recovery curve similar to that shown for paired SON stimulation.
摘要：
■在这项研究中，我们研究了同时和异步刺激两个三叉神经分支后的眨眼反射（BR）。目的是表征三叉神经和面部回路的生理学。
■我们进行了三组实验：记录BR反应i。眶上神经刺激（SON）后，精神神经刺激（MN）后，并且在18个健康个体中同时进行SON和MN刺激(SON+MN)之后;ii.在七个健康受试者中，在各种刺激间隔（ISIs）的MN（在强度引起的BR反应）之前的SON之后；iii在各种ISI的MN（在感觉阈值）之前的SON之后。我们比较了早期和晚期反应的幅度。
■同时进行SON+MN刺激后的R1振幅大于相同分支的单次刺激后的响应。同时刺激后,R2和R2c曲线下面积(AUC)小于单次刺激后获得的R2和R2cAUC的算术和.第二个实验提供了恢复兴奋性曲线。第三步,我们获得了R1的促进和后期反应的抑制。
■与单个刺激的算术和相比，SONMN刺激导致R1电路兴奋性增加；但是，后期反应的幅度没有增强。因此，我们已经提供了通过人类同时刺激来增强R1电路的证据，而后期反应的调节表现出与配对SON刺激相似的恢复曲线。
■我们进行了三组实验：记录BR反应i。眶上神经刺激（SON）后，精神神经刺激（MN）后，并且在18个健康个体中同时进行SON和MN刺激(SON+MN)之后;ii.在七个健康受试者中，在各种刺激间隔（ISIs）的MN（在强度引起的BR反应）之前的SON之后；iii在各种ISI的MN（在感觉阈值）之前的SON之后。我们比较了早期和晚期反应的幅度。
■同时进行SON+MN刺激后的R1振幅大于相同分支的单次刺激后的响应。同时刺激后,R2和R2c曲线下面积(AUC)小于单次刺激后获得的R2和R2cAUC的算术和.第二个实验提供了恢复兴奋性曲线。第三步,我们获得了R1的促进和后期反应的抑制。
■与单个刺激的算术和相比，SONMN刺激导致R1电路兴奋性增加；但是，后期反应的幅度没有增强。因此，我们已经提供了通过人类同时刺激来增强R1电路的证据，而后期反应的调节表现出与配对SON刺激相似的恢复曲线。
