PDF(Pubmed)
Abstract：
UNASSIGNED: Amnestic mild cognitive impairment (aMCI) is a risk factor for dementia, and thus, it is of interest to enlighten specific brain atrophy patterns in aMCI patients. We aim to define the longitudinal atrophy pattern in subcortical structures and its effect on cognition in patients with aMCI.
UNASSIGNED: Twenty patients with aMCI and 20 demographically matched healthy controls with baseline and longitudinal structural magnetic resonance imaging scans and neuropsychological assessments were studied. The algorithm FIRST (FMRIB\'s integrated registration and segmentation tool) was used to obtain volumes of subcortical structures (thalamus, putamen, caudate nucleus, nucleus accumbens, globus pallidus, hippocampus, and amygdala). Correlations between volumes and cognitive performance were assessed.
UNASSIGNED: Compared with healthy controls, aMCI demonstrated subcortical atrophies in the hippocampus (p = 0.001), nucleus accumbens (p = 0.003), and thalamus (p = 0.003) at baseline. Significant associations were found for the baseline volumes of the thalamus, nucleus accumbens, and hippocampus with memory, the thalamus with visuospatial skills.
UNASSIGNED: aMCI demonstrated subcortical atrophies associated with cognitive deficits. The thalamus, nucleus accumbens, and hippocampus may provide additional diagnostic information for aMCI.
UNASSIGNED: Twenty patients with aMCI and 20 demographically matched healthy controls with baseline and longitudinal structural magnetic resonance imaging scans and neuropsychological assessments were studied. The algorithm FIRST (FMRIB\'s integrated registration and segmentation tool) was used to obtain volumes of subcortical structures (thalamus, putamen, caudate nucleus, nucleus accumbens, globus pallidus, hippocampus, and amygdala). Correlations between volumes and cognitive performance were assessed.
UNASSIGNED: Compared with healthy controls, aMCI demonstrated subcortical atrophies in the hippocampus (p = 0.001), nucleus accumbens (p = 0.003), and thalamus (p = 0.003) at baseline. Significant associations were found for the baseline volumes of the thalamus, nucleus accumbens, and hippocampus with memory, the thalamus with visuospatial skills.
UNASSIGNED: aMCI demonstrated subcortical atrophies associated with cognitive deficits. The thalamus, nucleus accumbens, and hippocampus may provide additional diagnostic information for aMCI.
摘要：
■遗忘型轻度认知障碍（aMCI）是痴呆的危险因素，因此，启发aMCI患者的特定脑萎缩模式是有意义的。我们旨在定义皮质下结构的纵向萎缩模式及其对aMCI患者认知的影响。
■研究了20名aMCI患者和20名人口统计学匹配的健康对照者的基线和纵向结构磁共振成像扫描和神经心理学评估。算法FIRST(FMRIB的集成配准和分割工具)用于获得大量的皮层下结构(丘脑,壳核,尾状核,伏隔核,苍白球,海马体,和杏仁核）。评估体积和认知表现之间的相关性。
■与健康对照相比，aMCI表现出海马皮层下萎缩（p=0.001），伏隔核（p=0.003），和丘脑（p=0.003）在基线。发现丘脑的基线体积存在显着关联，伏隔核,和记忆的海马，具有视觉空间技能的丘脑。
■aMCI显示皮质下萎缩与认知缺陷相关。丘脑,伏隔核,和海马可以为aMCI提供额外的诊断信息。
■研究了20名aMCI患者和20名人口统计学匹配的健康对照者的基线和纵向结构磁共振成像扫描和神经心理学评估。算法FIRST(FMRIB的集成配准和分割工具)用于获得大量的皮层下结构(丘脑,壳核,尾状核,伏隔核,苍白球,海马体,和杏仁核）。评估体积和认知表现之间的相关性。
■与健康对照相比，aMCI表现出海马皮层下萎缩（p=0.001），伏隔核（p=0.003），和丘脑（p=0.003）在基线。发现丘脑的基线体积存在显着关联，伏隔核,和记忆的海马，具有视觉空间技能的丘脑。
■aMCI显示皮质下萎缩与认知缺陷相关。丘脑,伏隔核,和海马可以为aMCI提供额外的诊断信息。
