Abstract：
Pancreatic cancer remains a formidable challenge in oncology due to its aggressive nature and limited treatment options. The dense stroma surrounding pancreatic tumors not only provides structural support but also presents a formidable barrier to effective therapy, hindering drug penetration and immune cell infiltration. This review delves into the intricate interplay between stromal components and cancer cells, highlighting their impact on treatment resistance and prognosis. Strategies for stromal remodeling, including modulation of cancer-associated fibroblasts (CAFs), pancreatic stellate cells (PSCs) activation states, and targeting extracellular matrix (ECM) components, are examined for their potential to enhance drug penetration and improve therapeutic efficacy. Integration of stromal remodeling with conventional therapies, such as chemotherapy and immunotherapy, is discussed along with the emerging field of intelligent nanosystems for targeted drug delivery. This comprehensive overview underscores the importance of stromal remodeling in pancreatic cancer treatment and offers insights into promising avenues for future research and clinical translation.
摘要：
由于其侵袭性和有限的治疗选择，胰腺癌在肿瘤学中仍然是一个巨大的挑战。胰腺肿瘤周围的致密间质不仅提供了结构支持，而且为有效治疗提供了强大的屏障。阻碍药物渗透和免疫细胞浸润。这篇综述深入探讨了基质成分和癌细胞之间复杂的相互作用。强调它们对治疗抵抗和预后的影响。基质重塑的策略，包括调节癌症相关成纤维细胞（CAFs），胰腺星状细胞（PSC）激活状态，和靶向细胞外基质（ECM）成分，检查它们增强药物渗透和提高治疗效果的潜力。基质重塑与常规疗法的整合，比如化疗和免疫疗法，与用于靶向药物递送的智能纳米系统的新兴领域一起讨论。这个全面的概述强调了基质重塑在胰腺癌治疗中的重要性，并提供了对未来研究和临床转化的有希望的途径的见解。
