PDF(Pubmed)
Abstract：
Discrepancies in self-rated and observer-rated depression severity may underlie the basis for biological heterogeneity in depressive disorders and be an important predictor of outcomes and indicators to optimize intervention strategies. However, the neural mechanisms underlying this discrepancy have been understudied. This study aimed to examine the brain networks that represent the neural basis of the discrepancy between self-rated and observer-rated depression severity using resting-state functional MRI. To examine the discrepancy between self-rated and observer-rated depression severity, self- and observer-ratings discrepancy (SOD) was defined, and the higher and lower SOD groups were selected from depressed patients as participants showing extreme deviation. Resting-state functional MRI analysis was performed to examine regions with significant differences in functional connectivity in the two groups. The results showed that, in the higher SOD group compared to the lower SOD group, there was increased functional connectivity between the frontal pole and precuneus, both of which are subregions of the default mode network that have been reported to be associated with ruminative and self-referential thinking. These results provide insight into the association of brain circuitry with discrepancies between self- and observer-rated depression severity and may lead to more treatment-oriented diagnostic reclassification in the future.
摘要：
自我评估和观察者评估的抑郁严重程度的差异可能是抑郁症生物学异质性的基础，并且是优化干预策略的结果和指标的重要预测指标。然而,这种差异背后的神经机制尚未得到充分研究。这项研究旨在使用静息状态功能MRI检查代表自我评估和观察者评估的抑郁严重程度之间差异的神经基础的大脑网络。为了检查自我评估和观察者评估的抑郁严重程度之间的差异，定义了自我评级和观察者评级差异(SOD)，从抑郁症患者中选择SOD较高和较低的组作为表现出极端偏差的参与者。进行静息状态功能MRI分析，以检查两组功能连接存在显着差异的区域。结果表明,在较高的SOD组相比，较低的SOD组，额叶极和前突之间的功能连通性增加，这两个都是默认模式网络的子区域，据报道与反思和自我参照思维有关。这些结果提供了对大脑回路与自我和观察者评估的抑郁严重程度之间差异的关联的见解，并可能导致将来更多的以治疗为导向的诊断重新分类。
