Abstract：
OBJECTIVE: In the recent years creatine has been shown promising results in patients with neurodegenerative diseases, myopathies and dystrophies. Cardiovascular diseases could be another pathology that can benefit from creatine supplementation, considering the influence on the risk factors associated with the development of cardiovascular diseases including reduction in chronic inflammation, and improved control of hyperglycemia and dyslipidemia The aim of the present study was to investigate the impact of short-term creatine supplementation on cardiac and vascular health in older adults.
METHODS: Males between the ages of 55-80 were randomly assigned to three groups: creatine, placebo and control. Creatine or placebo was provided for 7-day supplementation, at a dose of 20 g/day. Testing was performed at the same time of the day at baseline and on the eighth day. Vascular responses were assessed using an arterial pulse wave velocity equipment, while cardiac assessment was performed using an impedance cardiography device.
RESULTS: The placebo group was older (71.1 ± 8.2 yr) compared to creatine (61.4 ± 5.2 yr) and control (62.5 ± 7.1 yr). Cardio-ankle vascular index improved just in the creatine group (8.7 ± 0.5 to 8.2 ± 0.5, p = 0.03). While the upstroke time of the placebo and control groups did not change after 7 days, the creatine group had a nonsignificant reduction, 178.9 ± 26.5 ms to 158.4 ± 28.6 ms, p = 0.07. Similar tendency was seen with the systolic blood pressures, while the placebo and control did not change, the creatine group showed nonsignificant improvement, especially on the right, 144.0 ± 12.7 mmHg to 136.1 ± 13.4 mmHg, p = 0.08. All three groups had similar responses in stroke volume (p = 0.61), contractility index (p = 0.64) and ejection fraction (p = 0.72).
CONCLUSIONS: In older adults, acute creatine supplementation can positively affect vascular parameters of arterial stiffness and atherosclerosis. Creatine supplementation has the potential to serve as a potent adjuvant in the management of CVD for older adults.
BACKGROUND: clinicaltrials.gov; ID: NCT05329480.
METHODS: Males between the ages of 55-80 were randomly assigned to three groups: creatine, placebo and control. Creatine or placebo was provided for 7-day supplementation, at a dose of 20 g/day. Testing was performed at the same time of the day at baseline and on the eighth day. Vascular responses were assessed using an arterial pulse wave velocity equipment, while cardiac assessment was performed using an impedance cardiography device.
RESULTS: The placebo group was older (71.1 ± 8.2 yr) compared to creatine (61.4 ± 5.2 yr) and control (62.5 ± 7.1 yr). Cardio-ankle vascular index improved just in the creatine group (8.7 ± 0.5 to 8.2 ± 0.5, p = 0.03). While the upstroke time of the placebo and control groups did not change after 7 days, the creatine group had a nonsignificant reduction, 178.9 ± 26.5 ms to 158.4 ± 28.6 ms, p = 0.07. Similar tendency was seen with the systolic blood pressures, while the placebo and control did not change, the creatine group showed nonsignificant improvement, especially on the right, 144.0 ± 12.7 mmHg to 136.1 ± 13.4 mmHg, p = 0.08. All three groups had similar responses in stroke volume (p = 0.61), contractility index (p = 0.64) and ejection fraction (p = 0.72).
CONCLUSIONS: In older adults, acute creatine supplementation can positively affect vascular parameters of arterial stiffness and atherosclerosis. Creatine supplementation has the potential to serve as a potent adjuvant in the management of CVD for older adults.
BACKGROUND: clinicaltrials.gov; ID: NCT05329480.
摘要：
目的：近年来，肌酸在神经退行性疾病患者中已显示出有希望的结果，肌病和营养不良。心血管疾病可能是另一种可以从补充肌酸中受益的病理，考虑到与心血管疾病的发展相关的危险因素的影响，包括减少慢性炎症，本研究的目的是研究短期补充肌酸对老年人心脏和血管健康的影响。
方法：将年龄在55-80岁之间的男性随机分为三组：肌酸，安慰剂和对照。提供肌酸或安慰剂7天补充，在20g/天的剂量。在基线和第八天在当天的相同时间进行测试。使用动脉脉搏波速度设备评估血管反应，而心脏评估是使用阻抗心动图设备进行的。
结果：安慰剂组年龄较大（71.1±8.2岁。)与肌酸(61.4±5.2年。)和对照（62.5±7.1年。).仅肌酸组的心踝血管指数改善（8.7±0.5至8.2±0.5，p=0.03）。而安慰剂组和对照组的上中风时间在7天后没有变化，肌酸组没有明显的减少，178.9±26.5ms到158.4±28.6ms，p=0.07。收缩压也有类似的趋势，而安慰剂和对照没有改变，肌酸组没有显着改善，尤其是在右边，144.0±12.7mmHg至136.1±13.4mmHg，p=0.08。所有三组的每搏输出量反应相似（p=0.61），收缩指数(p=0.64)和射血分数(p=0.72)。
结论：在老年人中，急性补充肌酸可以积极影响动脉僵硬度和动脉粥样硬化的血管参数。补充肌酸有可能作为老年人CVD治疗的有效佐剂。
背景：clinicaltrials.gov；ID：NCT05329480。
方法：将年龄在55-80岁之间的男性随机分为三组：肌酸，安慰剂和对照。提供肌酸或安慰剂7天补充，在20g/天的剂量。在基线和第八天在当天的相同时间进行测试。使用动脉脉搏波速度设备评估血管反应，而心脏评估是使用阻抗心动图设备进行的。
结果：安慰剂组年龄较大（71.1±8.2岁。)与肌酸(61.4±5.2年。)和对照（62.5±7.1年。).仅肌酸组的心踝血管指数改善（8.7±0.5至8.2±0.5，p=0.03）。而安慰剂组和对照组的上中风时间在7天后没有变化，肌酸组没有明显的减少，178.9±26.5ms到158.4±28.6ms，p=0.07。收缩压也有类似的趋势，而安慰剂和对照没有改变，肌酸组没有显着改善，尤其是在右边，144.0±12.7mmHg至136.1±13.4mmHg，p=0.08。所有三组的每搏输出量反应相似（p=0.61），收缩指数(p=0.64)和射血分数(p=0.72)。
结论：在老年人中，急性补充肌酸可以积极影响动脉僵硬度和动脉粥样硬化的血管参数。补充肌酸有可能作为老年人CVD治疗的有效佐剂。
背景：clinicaltrials.gov；ID：NCT05329480。
