Abstract：
The classic Astragalus-Cassia twig drug pair has a long history of proven efficacy. However, a fewer studies on material basis of the Astragalus and Cassia twig decoction (ACD) was researched at present. The method of UPLC-Q-TOF-MS for classifying and identifying the main chemical components of ACD was established and the differences in composition between single decoction and co-decoction were compared by using HPLC-UV. The therapeutic role of ACD on type 2 diabetes (T2D) rats was investigated. Thirty-five compounds were resolved from the ACD. Fifteen compounds were deduced from the decoction of Astragalus, whereas nine compounds were identified from Cassia twig. Pairing of herbs make a significant effect on the chemical composition of herbal decoction. ACD can play a more obvious role in alleviating the symptoms of T2D rats, compared to the application of single herb.
摘要：
经典的黄芪-决明子小枝药物对具有悠久的疗效。然而,目前对黄芪桂枝汤（ACD）物质基础的研究较少。建立了UPLC-Q-TOF-MS对ACD主要化学成分进行分类鉴定的方法，并利用HPLC-UV比较了单汤和共汤的成分差异。研究了ACD对2型糖尿病（T2D）大鼠的治疗作用。从ACD中拆分出35种化合物。从黄芪汤剂中推导出15个化合物，而从决明子枝中鉴定出9种化合物。中药配对对中药汤剂的化学成分有显着影响。ACD对T2D大鼠的症状有较明显的缓解作用。与单一草药的应用相比。
