%0 Journal Article
%T Chemical detection and analysis of Astragalus-Cassia twig drug pair using UHPLC-Q-TOF-MS and HPLC-UV methods.
%A Yue L
%A Ni-Ni J
%A Long W
%A Xing-Yu Z
%A Shuai W
%A Meng-Jun P
%A Xiang L
%A Xiao-Qin C
%J Fitoterapia
%V 177
%N 0
%D 2024 Sep 22
%M 39047846
%F 3.204
%R 10.1016/j.fitote.2024.106129
%X The classic Astragalus-Cassia twig drug pair has a long history of proven efficacy. However, a fewer studies on material basis of the Astragalus and Cassia twig decoction (ACD) was researched at present. The method of UPLC-Q-TOF-MS for classifying and identifying the main chemical components of ACD was established and the differences in composition between single decoction and co-decoction were compared by using HPLC-UV. The therapeutic role of ACD on type 2 diabetes (T2D) rats was investigated. Thirty-five compounds were resolved from the ACD. Fifteen compounds were deduced from the decoction of Astragalus, whereas nine compounds were identified from Cassia twig. Pairing of herbs make a significant effect on the chemical composition of herbal decoction. ACD can play a more obvious role in alleviating the symptoms of T2D rats, compared to the application of single herb.