METHODS: The data for this study were sourced from 7257 participants who took part in the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2016. The target population consisted of adults with reliable HSV-2 plasma results, and alcohol consumption was assessed using self-report methods. We evaluated the odds ratio (OR) and 95% confidence interval (CI) for the association between alcohol consumption and HSV-2 infection. These estimations were derived from a logistic regression model that was adjusted for key confounding factors. Subgroup analysis specifically focused on alcohol consumption, and the interaction between HSV-2 infection, alcohol consumption, and other variables was assessed through stratified analysis.
RESULTS: Among the 7,257 participants included, 89.8% (6,518/7,257) reported varying levels of alcohol consumption history. Compared to individuals who never drinkers, the adjusted odds ratios (ORs) for former drinkers, light drinkers, moderate drinkers, and heavy drinkers were 1.79 (95% CI: 1.34-2.4, p < 0.001), 1.38 (95% CI: 1.07-1.77, p = 0.012), 1.49 (95% CI: 1.15-1.94, p = 0.003), and 1.47 (95% CI: 1.14-1.9, p = 0.003), respectively. The results remained stable in subgroup analyses and sensitivity analyses.
CONCLUSIONS: Current research indicates that individuals with a history of alcohol consumption exhibit a higher risk of HSV-2 infection compared to those who have never drinkers.
方法:本研究的数据来自2009年至2016年参加国家健康和营养调查(NHANES)的7257名参与者。目标人群包括具有可靠HSV-2血浆结果的成年人,使用自我报告方法评估饮酒量.我们评估了饮酒与HSV-2感染之间的关联的比值比(OR)和95%置信区间(CI)。这些估计来自针对关键混杂因素进行调整的逻辑回归模型。亚组分析特别关注饮酒,和HSV-2感染之间的相互作用,酒精消费,其他变量通过分层分析进行评估.
结果:在包括的7,257名参与者中,89.8%(6,518/7,257)报告了不同水平的饮酒史。与从不喝酒的人相比,前饮酒者的调整后赔率比(OR),轻度饮酒者,适度饮酒者,重度饮酒者为1.79(95%CI:1.34-2.4,p<0.001),1.38(95%CI:1.07-1.77,p=0.012),1.49(95%CI:1.15-1.94,p=0.003),和1.47(95%CI:1.14-1.9,p=0.003),分别。亚组分析和敏感性分析结果保持稳定。
结论:目前的研究表明,与从未饮酒的人相比,有饮酒史的人感染HSV-2的风险更高。