Abstract：
Postprandial regulation of the gastric emptying (GE) rate plays an important role in food intake. Although oral sweetening with glucose may accelerate GE, the effects of different sweetness intensities of glucose (10% and 20%, w/v) and other energy sweeteners (e.g. fructose and sucrose) remain uncertain. The purpose of this study was to determine the effects of different glucose concentrations (Experiment 1) and different sugars with the same sweet taste intensity (Experiment 2) on postprandial GE. In both experiments, after ingesting a 200 kcal carbohydrate solution containing 50 g of maltodextrin, participants repeatedly sipped, but did not swallow, one of three (water, 10% and 20%, w/v glucose) or four (water and equally sweet 20%, w/v glucose, 12%, w/v fructose, and 14%, w/v sucrose) solutions for 1 min every 5 min over a 30 min period. GE was evaluated by measuring the temporal change in the cross-sectional area of the gastric antrum using ultrasound. In Experiment 1, oral stimulation with 20% (w/v) glucose resulted in greater GE than the control stimulus (i.e. water), but the effect of stimulation with 10% (w/v) glucose on GE was not different from that of the control stimulus. In Experiment 2, stimulation with 20% (w/v) glucose or 12% (w/v) fructose resulted in greater GE than the control stimulus. However, the effect of stimulation with 14% (w/v) sucrose on GE did not differ from that of the control stimulus. Consequently, oral stimulation with glucose or fructose solutions of moderate to high sweetness following a meal facilitates postprandial GE.
摘要：
餐后调节胃排空（GE）率在食物摄入中起重要作用。尽管口服葡萄糖甜味可能会加速GE，葡萄糖(10%和20%w/v)和其他能量甜味剂的不同甜味强度的影响(例如，果糖和蔗糖）仍然不确定。这项研究的目的是确定不同葡萄糖浓度（实验1）和具有相同甜味强度的不同糖（实验2）对餐后GE的影响。在这两个实验中,在摄入含有50克麦芽糊精的200千卡碳水化合物溶液后，参与者反复啜饮，但没有吞咽，三个（水，10％和20％w/v葡萄糖）或4（水和同样甜的20％w/v葡萄糖，12%w/v果糖，和14％w/v蔗糖）溶液在30分钟内每5分钟1分钟。通过使用超声测量胃窦横截面积的时间变化来评估GE。在实验1中，使用20％w/v葡萄糖的口腔刺激导致比对照刺激更大的GE（即，水),但是用10％w/v葡萄糖刺激对GE的影响与对照刺激没有差异。在实验2中,用20%w/v葡萄糖或12%w/v果糖刺激导致比对照刺激更大的GE。然而,14％w/v蔗糖对GE的刺激效果与对照刺激没有差异。因此,餐后用中等至高甜度的葡萄糖或果糖溶液进行口服刺激可促进餐后GE。
