Abstract：
BACKGROUND: The aim of this study was to summarize existing data and perform technological prospecting on the effect of incorporating antifungal agents into denture base materials in inhibiting Candida spp., as well as to explore the antimicrobial properties of these materials.
METHODS: A comprehensive electronic search was carried out in six major bibliographic databases (PubMed, Scopus, Embase, Cochrane Library, Web of Science and Lilacs) until February 2024. In addition, international patent databases were also examined. The search process, study and patent selection, data extraction and risk of bias assessment were carried out independently by researchers. The collected data underwent qualitative analysis.
RESULTS: A total of 10 718 articles were identified in the searched databases, of which 40 documents were included for qualitative data analysis (articles: 31; patents: 9). The majority of the studies focused on investigating tissue conditioners (n = 14) and acrylic resins (n = 14). The primary antifungal agents studied were nystatin (n = 15) and fluconazole (n = 13). The most commonly utilized microbiological evaluation methodology was the agar diffusion test (n = 16), followed by the microdilution (n = 7) and biofilm formation assays (n = 7). All of the studies investigated the inhibitory effect of these materials against Candida species.
CONCLUSIONS: The incorporation of antifungal agents into denture base materials has been extensively studied and has shown a significant inhibitory response against Candida spp. across various methodological assays.
METHODS: A comprehensive electronic search was carried out in six major bibliographic databases (PubMed, Scopus, Embase, Cochrane Library, Web of Science and Lilacs) until February 2024. In addition, international patent databases were also examined. The search process, study and patent selection, data extraction and risk of bias assessment were carried out independently by researchers. The collected data underwent qualitative analysis.
RESULTS: A total of 10 718 articles were identified in the searched databases, of which 40 documents were included for qualitative data analysis (articles: 31; patents: 9). The majority of the studies focused on investigating tissue conditioners (n = 14) and acrylic resins (n = 14). The primary antifungal agents studied were nystatin (n = 15) and fluconazole (n = 13). The most commonly utilized microbiological evaluation methodology was the agar diffusion test (n = 16), followed by the microdilution (n = 7) and biofilm formation assays (n = 7). All of the studies investigated the inhibitory effect of these materials against Candida species.
CONCLUSIONS: The incorporation of antifungal agents into denture base materials has been extensively studied and has shown a significant inhibitory response against Candida spp. across various methodological assays.
摘要：
背景：这项研究的目的是总结现有数据，并对将抗真菌药物掺入义齿基托材料中抑制念珠菌的效果进行技术研究。,以及探索这些材料的抗菌性能。
方法：在六个主要书目数据库（PubMed，Scopus,Embase,科克伦图书馆,WebofScience和丁香花）至2024年2月。此外,还审查了国际专利数据库。搜索过程,研究和专利选择，数据提取和偏倚风险评估由研究人员独立进行。对收集的数据进行定性分析。
结果：在检索到的数据库中，共识别出10718篇文章，其中包括40篇文献进行定性数据分析(文章：31篇；专利：9篇)。大多数研究集中在研究组织调理剂(n=14)和丙烯酸树脂(n=14)。研究的主要抗真菌剂是制霉菌素（n=15）和氟康唑（n=13）。最常用的微生物评价方法是琼脂扩散试验(n=16)，然后进行微量稀释(n=7)和生物膜形成测定(n=7)。所有研究都研究了这些材料对念珠菌物种的抑制作用。
结论：在义齿基托材料中掺入抗真菌剂已被广泛研究，并显示出对念珠菌的显著抑制反应。在各种方法学分析中。
方法：在六个主要书目数据库（PubMed，Scopus,Embase,科克伦图书馆,WebofScience和丁香花）至2024年2月。此外,还审查了国际专利数据库。搜索过程,研究和专利选择，数据提取和偏倚风险评估由研究人员独立进行。对收集的数据进行定性分析。
结果：在检索到的数据库中，共识别出10718篇文章，其中包括40篇文献进行定性数据分析(文章：31篇；专利：9篇)。大多数研究集中在研究组织调理剂(n=14)和丙烯酸树脂(n=14)。研究的主要抗真菌剂是制霉菌素（n=15）和氟康唑（n=13）。最常用的微生物评价方法是琼脂扩散试验(n=16)，然后进行微量稀释(n=7)和生物膜形成测定(n=7)。所有研究都研究了这些材料对念珠菌物种的抑制作用。
结论：在义齿基托材料中掺入抗真菌剂已被广泛研究，并显示出对念珠菌的显著抑制反应。在各种方法学分析中。
