PDF(Pubmed)
Abstract：
Cancer-associated cognitive deficits following chemotherapy have received increased attention in clinical research. Exercise has been shown to preserve cognitive function in cancer patients, though the overall effect is mixed. Here we present a scoping review of the published literature summarizing methods used to assess cognitive function in exercise oncology trials. Methods: PubMed, PsycINFO and CINAHL databases were searched using keywords \"cognition,\" \"cancer\" OR \"neoplasm\" OR \"tumor,\" \"chemotherapy\" and \"exercise\" OR \"physical activity.\" Studies eligible for inclusion include prospective studies that were published in English in peer-reviewed journals that include a method of assessing cognitive function in adult cancer patients, in which an exercise modality or method of quantifying exercise habits was evident. Studies were excluded if they included a pediatric population, patients that were not diagnosed with cancer, or were systematic/narrative/scoping reviews, protocol papers or dissertation/theses. Results: A total of 29 studies met the inclusion criteria. In total, 29 unique assessments were used to evaluate cognitive function, including patient-reported outcomes (PROs; n = 8) and objective (n = 21) methods. More than half (n = 17) of included studies relied on PROs while 12 studies utilized objective measures of cognitive function Cognitive domains of the PROs were limited in scope, focusing on memory and attention/concentration while the objective measures were broader and inclusive of multiple domains. Conclusion: The results of this review indicate that mixed approaches to evaluating cognitive function in cancer patients pose a major limitation to understanding the role of exercise as an integrative approach. The evidence demonstrates a need for more uniform assessment of cognitive function in exercise oncology trials.
摘要：
化疗后癌症相关的认知缺陷在临床研究中受到越来越多的关注。运动已被证明可以保护癌症患者的认知功能，虽然整体效果参差不齐。在这里，我们对已发表的文献进行范围审查，总结了用于评估运动肿瘤学试验中认知功能的方法。方法:PubMed,使用关键词“认知”搜索PsycINFO和CINAHL数据库，\"\"癌症\"或\"肿瘤\"或\"肿瘤，\"\"化疗\"和\"运动\"或\"身体活动。符合纳入条件的研究包括在同行评审期刊上以英文发表的前瞻性研究，其中包括评估成年癌症患者认知功能的方法。其中锻炼方式或量化锻炼习惯的方法很明显。如果研究包括儿科人群，则将其排除在外，没有被诊断出癌症的病人，或者是系统/叙述性/范围审查，协议论文或论文/论文。结果：共有29项研究符合纳入标准。总的来说,29项独特评估用于评估认知功能，包括患者报告的结果（PRO；n=8）和客观（n=21）方法。纳入研究的一半以上（n=17）依赖于PRO，而12项研究使用了认知功能的客观测量，PRO的认知领域范围有限，重点是记忆力和注意力/注意力，而客观指标更广泛，包括多个领域。结论：本综述的结果表明，评估癌症患者认知功能的混合方法对理解运动作为综合方法的作用构成了重大限制。证据表明，在运动肿瘤学试验中需要对认知功能进行更统一的评估。
