PDF(Pubmed)
Abstract：
UNASSIGNED: Emerging issues in the management of major depressive disorder (MDD) comprise a nonadherence to treatment and treatment failures, depressive recurrence and relapses, misidentification of incoming exacerbated phases and consequently, a chronification of depression. While antidepressant drugs constitute the standard of care for MDD, effective psychosocial interventions are needed to reduce rehospitalizations and other adverse events. The present study primarily investigated the effects and impact of implementing a structured psychoeducational intervention on the clinical course of MDD.
UNASSIGNED: A non-randomized comparative, pragmatic, pilot, single-center study of adults with nonpsychotic moderate or severe episode of MDD recently discharged from a psychiatric hospitalization. The consecutive subjects were allocated either to the intervention group (N=49) or to the attention control group (N=47), based on their preference. The psychoeducational intervention was based on a modified Munoz\'s Depression Prevention Course. Subjects were followed up prospectively for two years.
UNASSIGNED: The absolute changes in Beck anxiety inventory scale, Zung\'s depression questionnaire, and Montgomery and Äsberg depression rating scale (MADRS) total scores at 6-month follow-up were comparable between the two groups. There were lower rates of the rehospitalization within one year (2.1% vs. 16.7%; P<0.001) and less rehospitalizations after one year (6.3% vs. 25%; P<0.001), lower rates of the ongoing sickness absence (11.5% vs. 29.2%; P<0.001), less persons with disability due to MDD at 1-year follow-up (1% vs. 11.5%; P=0.002), and less nonadherent subjects who self-discontinued treatment (6.3% vs. 28.1%; P<0.001) among participants in the intervention group compared to the control group. The disability due to MDD at 1-year follow-up was predicted by the absence of the psychoeducational intervention (P=0.002) and by the MADRS total score at 6-month follow-up (OR 1.10; 95% CI 1.003-1.195; P=0.044). Qualitative data indicated the intervention was desired and appreciated by the participants, as well as being practical to implement in Slovakian clinical settings.
UNASSIGNED: The results suggest the psychoeducational intervention based on a modified Munoz\'s Depression Prevention Course has beneficial effects in adults with MDD recently discharged from a psychiatric hospitalization. The findings implicate the psychoeducational intervention may offer a new approach to the prevention of depressive relapses.
UNASSIGNED: A non-randomized comparative, pragmatic, pilot, single-center study of adults with nonpsychotic moderate or severe episode of MDD recently discharged from a psychiatric hospitalization. The consecutive subjects were allocated either to the intervention group (N=49) or to the attention control group (N=47), based on their preference. The psychoeducational intervention was based on a modified Munoz\'s Depression Prevention Course. Subjects were followed up prospectively for two years.
UNASSIGNED: The absolute changes in Beck anxiety inventory scale, Zung\'s depression questionnaire, and Montgomery and Äsberg depression rating scale (MADRS) total scores at 6-month follow-up were comparable between the two groups. There were lower rates of the rehospitalization within one year (2.1% vs. 16.7%; P<0.001) and less rehospitalizations after one year (6.3% vs. 25%; P<0.001), lower rates of the ongoing sickness absence (11.5% vs. 29.2%; P<0.001), less persons with disability due to MDD at 1-year follow-up (1% vs. 11.5%; P=0.002), and less nonadherent subjects who self-discontinued treatment (6.3% vs. 28.1%; P<0.001) among participants in the intervention group compared to the control group. The disability due to MDD at 1-year follow-up was predicted by the absence of the psychoeducational intervention (P=0.002) and by the MADRS total score at 6-month follow-up (OR 1.10; 95% CI 1.003-1.195; P=0.044). Qualitative data indicated the intervention was desired and appreciated by the participants, as well as being practical to implement in Slovakian clinical settings.
UNASSIGNED: The results suggest the psychoeducational intervention based on a modified Munoz\'s Depression Prevention Course has beneficial effects in adults with MDD recently discharged from a psychiatric hospitalization. The findings implicate the psychoeducational intervention may offer a new approach to the prevention of depressive relapses.
摘要：
■重度抑郁症(MDD)管理中出现的问题包括不坚持治疗和治疗失败。抑郁复发和复发，错误地识别了传入的加剧阶段，因此，抑郁症的慢性化。虽然抗抑郁药物构成了MDD的护理标准，需要有效的心理社会干预措施来减少再住院和其他不良事件.本研究主要调查了实施结构化心理教育干预对MDD临床过程的影响和影响。
■非随机比较，务实,飞行员,单中心研究对象为非精神病性中度或重度MDD患者,近期从精神病住院出院.连续受试者被分配到干预组（N=49）或注意力对照组（N=47），基于他们的偏好。心理教育干预是基于改良的Munoz抑郁症预防课程。对受试者进行了为期两年的前瞻性随访。
■贝克焦虑量表的绝对变化，Zung的抑郁问卷，在6个月的随访中，蒙哥马利和阿斯贝格抑郁量表（MADRS）的总分在两组之间具有可比性。一年内再住院率较低(2.1%vs.16.7%；P<0.001），一年后再住院人数较少（6.3%vs.25%；P<0.001），持续缺病率较低(11.5%vs.29.2%；P<0.001），1年随访时，因MDD而残疾的人较少(1%vs.11.5%；P=0.002），自我停止治疗的非依从性受试者较少(6.3%vs.与对照组相比，干预组的参与者为28.1%；P<0.001）。通过缺乏心理教育干预（P=0.002）和6个月随访时的MADRS总分（OR1.10；95％CI1.003-1.195；P=0.044），可以预测1年随访时MDD所致的残疾。定性数据表明干预是参与者希望和赞赏的，以及在斯洛伐克临床环境中实施的实用性。
■结果表明，基于改良的Munoz抑郁症预防课程的心理教育干预措施对最近从精神病住院出院的患有MDD的成年人具有有益作用。研究结果表明，心理教育干预可能为预防抑郁症复发提供了一种新方法。
■非随机比较，务实,飞行员,单中心研究对象为非精神病性中度或重度MDD患者,近期从精神病住院出院.连续受试者被分配到干预组（N=49）或注意力对照组（N=47），基于他们的偏好。心理教育干预是基于改良的Munoz抑郁症预防课程。对受试者进行了为期两年的前瞻性随访。
■贝克焦虑量表的绝对变化，Zung的抑郁问卷，在6个月的随访中，蒙哥马利和阿斯贝格抑郁量表（MADRS）的总分在两组之间具有可比性。一年内再住院率较低(2.1%vs.16.7%；P<0.001），一年后再住院人数较少（6.3%vs.25%；P<0.001），持续缺病率较低(11.5%vs.29.2%；P<0.001），1年随访时，因MDD而残疾的人较少(1%vs.11.5%；P=0.002），自我停止治疗的非依从性受试者较少(6.3%vs.与对照组相比，干预组的参与者为28.1%；P<0.001）。通过缺乏心理教育干预（P=0.002）和6个月随访时的MADRS总分（OR1.10；95％CI1.003-1.195；P=0.044），可以预测1年随访时MDD所致的残疾。定性数据表明干预是参与者希望和赞赏的，以及在斯洛伐克临床环境中实施的实用性。
■结果表明，基于改良的Munoz抑郁症预防课程的心理教育干预措施对最近从精神病住院出院的患有MDD的成年人具有有益作用。研究结果表明，心理教育干预可能为预防抑郁症复发提供了一种新方法。
