PDF(Pubmed)
Abstract：
Thermoregulation is a fundamental mechanism for maintaining homeostasis in living organisms because temperature affects essentially all biochemical and physiological processes. Effector responses to internal and external temperature cues are critical for achieving effective thermoregulation by controlling heat production and dissipation. Thermoregulation can be classified as physiological, which is observed primarily in higher organisms (homeotherms), and behavioral, which manifests as crucial physiological functions that are conserved across many species. Neuronal pathways for physiological thermoregulation are well-characterized, but those associated with behavioral regulation remain unclear. Thermoreceptors, including Transient Receptor Potential (TRP) channels, play pivotal roles in thermoregulation. Mammals have 11 thermosensitive TRP channels, the functions for which have been elucidated through behavioral studies using knockout mice. Behavioral thermoregulation is also observed in ectotherms such as the fruit fly, Drosophila melanogaster. Studies of Drosophila thermoregulation helped elucidate significant roles for thermoreceptors as well as regulatory actions of membrane lipids in modulating the activity of both thermosensitive TRP channels and thermoregulation. This review provides an overview of thermosensitive TRP channel functions in behavioral thermoregulation based on results of studies involving mice or Drosophila melanogaster.
摘要：
体温调节是维持生物体内稳态的基本机制，因为温度基本上影响所有生化和生理过程。对内部和外部温度线索的效应物响应对于通过控制热量产生和耗散来实现有效的温度调节至关重要。体温调节可以归类为生理，这主要在高等生物中观察到(恒温动物)，和行为，这表现为许多物种保守的重要生理功能。生理体温调节的神经元通路有很好的特征，但与行为调节相关的因素仍不清楚。热感受器,包括瞬态受体电位（TRP）通道，在体温调节中起着举足轻重的作用。哺乳动物有11个热敏TRP通道,通过使用敲除小鼠的行为研究已经阐明了其功能。在果蝇等外温动物中也观察到了行为的体温调节，黑腹果蝇.果蝇体温调节的研究有助于阐明热受体的重要作用以及膜脂质在调节热敏TRP通道和体温调节中的调节作用。这篇综述根据涉及小鼠或果蝇的研究结果，概述了热敏TRP通道在行为体温调节中的功能。
