PDF(Pubmed)
Abstract：
This is a case of an elderly patient diagnosed with acute myeloid leukemia (AML). While morphological findings, including numerous long, slender, cigar-shaped Auer rods, suggested AML with t(8;21), cytogenetic and FISH analysis revealed abnormalities in chromosome 11 and the KMT2A (MLL) gene. The patient also exhibited double minutes, typically seen in AML and linked to a complex karyotype and poor prognosis. Correlating morphological findings with molecular genetics and cytogenetics is crucial for accurate diagnosis and treatment.
摘要：
这是诊断为急性髓细胞性白血病（AML）的老年患者的病例。虽然形态学发现，包括许多长，纤细，雪茄形的奥尔棒，建议使用t（8；21）的AML，细胞遗传学和FISH分析显示11号染色体和KMT2A（MLL）基因异常。患者还表现出双倍的时间，通常见于AML，并与复杂的核型和不良预后有关。将形态学发现与分子遗传学和细胞遗传学相关联对于准确诊断和治疗至关重要。
