{Reference Type}: Case Reports
{Title}: A case of AML with complex karyotype and chromosomal rearrangement of KMT2A.
{Author}: Moshref Razavi H;Minor A;
{Journal}: Clin Case Rep
{Volume}: 12
{Issue}: 7
{Year}: 2024 Jul
暂无{DOI}: 10.1002/ccr3.9139
{Abstract}: This is a case of an elderly patient diagnosed with acute myeloid leukemia (AML). While morphological findings, including numerous long, slender, cigar-shaped Auer rods, suggested AML with t(8;21), cytogenetic and FISH analysis revealed abnormalities in chromosome 11 and the KMT2A (MLL) gene. The patient also exhibited double minutes, typically seen in AML and linked to a complex karyotype and poor prognosis. Correlating morphological findings with molecular genetics and cytogenetics is crucial for accurate diagnosis and treatment.