Abstract：
UNASSIGNED: Although the association between a history of infertility treatment and perinatal depression has been investigated, most research has been cross-sectional and has not used diagnostic assessment tools.
UNASSIGNED: This study investigates longitudinally the association between a history of infertility treatment and perinatal depression using WHO-Composite International Diagnostic Interview 3.0 (WHO-CIDI 3.0) and the Edinburgh Postnatal Depression Scale (EPDS).
UNASSIGNED: This study used data (N = 2,435) from the control group of a randomised controlled trial on a sample of pregnant women. Survival analysis was used to examine the influence of infertility treatment on perinatal depressive disorder evaluated by WHO-CIDI 3.0. The EPDS scores at four time points (T1 [baseline]: 18 ± 2 weeks gestation, T2: 32 weeks gestation, T3: 1 week postpartum, T4: 3 months postpartum) were analysed using generalised mixed model analysis.
UNASSIGNED: The risk of experiencing a major depressive episode evaluated by WHO-CIDI 3.0 did not significantly differ between women conceiving through infertility treatment and those conceiving spontaneously (adjusted hazard ratio = 1.64, p = 0.109). The longitudinal analysis demonstrated that EPDS scores significantly increased at T3 and T4 among women conceiving through infertility treatment compared with those conceiving spontaneously (adjusted estimates of fixed effect from T1 to T3: 1.17, p < 0.01; from T1 to T4: 0.71, p = 0.022).
UNASSIGNED: Women conceiving through infertility treatment were not found to have a higher risk of diagnosable perinatal depressive disorder than those conceiving naturally. However, a history of infertility treatment can marginally increase sub-clinical postpartum depressive symptoms.
UNASSIGNED: This study investigates longitudinally the association between a history of infertility treatment and perinatal depression using WHO-Composite International Diagnostic Interview 3.0 (WHO-CIDI 3.0) and the Edinburgh Postnatal Depression Scale (EPDS).
UNASSIGNED: This study used data (N = 2,435) from the control group of a randomised controlled trial on a sample of pregnant women. Survival analysis was used to examine the influence of infertility treatment on perinatal depressive disorder evaluated by WHO-CIDI 3.0. The EPDS scores at four time points (T1 [baseline]: 18 ± 2 weeks gestation, T2: 32 weeks gestation, T3: 1 week postpartum, T4: 3 months postpartum) were analysed using generalised mixed model analysis.
UNASSIGNED: The risk of experiencing a major depressive episode evaluated by WHO-CIDI 3.0 did not significantly differ between women conceiving through infertility treatment and those conceiving spontaneously (adjusted hazard ratio = 1.64, p = 0.109). The longitudinal analysis demonstrated that EPDS scores significantly increased at T3 and T4 among women conceiving through infertility treatment compared with those conceiving spontaneously (adjusted estimates of fixed effect from T1 to T3: 1.17, p < 0.01; from T1 to T4: 0.71, p = 0.022).
UNASSIGNED: Women conceiving through infertility treatment were not found to have a higher risk of diagnosable perinatal depressive disorder than those conceiving naturally. However, a history of infertility treatment can marginally increase sub-clinical postpartum depressive symptoms.
摘要：
■尽管已经研究了不孕症治疗史与围产期抑郁症之间的关联，大多数研究是横断面的,没有使用诊断评估工具.
本研究使用WHO-综合国际诊断访谈3.0（WHO-CIDI3.0）和爱丁堡产后抑郁量表（EPDS）纵向调查了不孕症治疗史与围产期抑郁之间的关系。
■本研究使用的数据（N=2,435）来自对孕妇样本的随机对照试验的对照组。生存分析用于检查WHO-CIDI3.0评估的不孕症治疗对围产期抑郁症的影响。四个时间点的EPDS评分（T1[基线]：妊娠14±2周，T2：妊娠32周，T3：产后1周，T4：产后3个月）使用广义混合模型分析进行分析。
■通过WHO-CIDI3.0评估的经历重度抑郁发作的风险在通过不孕症治疗受孕的女性和自发受孕的女性之间没有显着差异（调整后的风险比=1.64，p=0.109）。纵向分析表明，与自然受孕的女性相比，通过不孕症治疗受孕的女性在T3和T4时的EPDS得分显着增加（从T1到T3的固定效应调整估计值：1.17，p<0.01；从T1到T4：0.71，p=0.022）。
■没有发现通过不孕症治疗受孕的女性比自然受孕的女性患可诊断的围产期抑郁症的风险更高。然而,有不孕症治疗史可以轻微增加产后亚临床抑郁症状.
本研究使用WHO-综合国际诊断访谈3.0（WHO-CIDI3.0）和爱丁堡产后抑郁量表（EPDS）纵向调查了不孕症治疗史与围产期抑郁之间的关系。
■本研究使用的数据（N=2,435）来自对孕妇样本的随机对照试验的对照组。生存分析用于检查WHO-CIDI3.0评估的不孕症治疗对围产期抑郁症的影响。四个时间点的EPDS评分（T1[基线]：妊娠14±2周，T2：妊娠32周，T3：产后1周，T4：产后3个月）使用广义混合模型分析进行分析。
■通过WHO-CIDI3.0评估的经历重度抑郁发作的风险在通过不孕症治疗受孕的女性和自发受孕的女性之间没有显着差异（调整后的风险比=1.64，p=0.109）。纵向分析表明，与自然受孕的女性相比，通过不孕症治疗受孕的女性在T3和T4时的EPDS得分显着增加（从T1到T3的固定效应调整估计值：1.17，p<0.01；从T1到T4：0.71，p=0.022）。
■没有发现通过不孕症治疗受孕的女性比自然受孕的女性患可诊断的围产期抑郁症的风险更高。然而,有不孕症治疗史可以轻微增加产后亚临床抑郁症状.
